Undersulfation of chondroitin sulfate and abnormal cartilage tissue by the signaling of the receptor of PTH/PTHrP

PTH/PTHrP 受体信号传导导致硫酸软骨素硫酸化不足和异常软骨组织

• 批准号: 22890009
• 负责人: WADA Satoshi
• 金额: $ 1.72万
• 依托单位: Tsurumi University (2011)Hokkaido University (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22890009/
• 关键词: コンドロイチン硫酸の低硫酸化; PTH/PTHrPシグナル; 細胞外基質合成異常; 軟骨組織異常; 軟骨細胞の増殖・分化

The objectives of this study are to elucidate the relationship between not only differentiation of chondrocytes and extracellular matrix, but also proliferation of them. We performed immunohistochemical analysis in cartilage of the spheno-occipital synchondrosis of BALB/c-bm/bm mice. The expression of collagen II and collagen X were expressed irregularly in the spheno-occipital synchondrosis. Additionally, the expression of alkaline phosphatase was expressed in the center of the spheno-occipital synchondrosis, whereas that of the PCNA was expressed around the spheno-occipital synchondrosis. In summary, these results presented that the differentiation of hypertrophic chondrocytes was enhanced in the center of the spheno-occipital synchondrosis, whereas the proliferation of chondrocytes was increased around the spheno-occipital synchondrosis.

本研究的目的是阐明软骨细胞和细胞外基质的分化以及它们的增殖之间的关系。我们对 BALB/c-bm/bm 小鼠蝶枕软骨联合症的软骨进行了免疫组织化学分析。蝶枕联合软骨组织中II型胶原和X型胶原的表达不规则。此外，碱性磷酸酶的表达在蝶枕联合软骨的中心表达，而PCNA的表达在蝶枕联合软骨周围表达。总之，这些结果表明，蝶枕联合软骨中心肥大软骨细胞的分化增强，而蝶枕联合软骨周围软骨细胞的增殖增加。

项目成果

Histological evaluation of the nasal septal cartilage in bm/bm mouse that spontaneously induces malocclusion

自发引起错牙合的 bm/bm 小鼠鼻中隔软骨的组织学评估

• 发表时间: 2011
• 作者: K.Takahashi;S.Wada;et al
• 通讯作者: et al

Histological study of the nasal septal cartilage in BALB/c-bm/bm mouse which spontaneously induces malocclusion

BALB/c-bm/bm自发性错牙合小鼠鼻中隔软骨的组织学研究

• DOI: 10.1111/j.1601-6343.2011.01538.x
• 发表时间: 2012
• 期刊: Orthodontics & craniofacial research
• 影响因子: 3.1
• 作者: Takahashi K;Kajii TS;Tsukamoto Y;Saito F;Wada S;Sugawara-Kato Y;Iida J.
• 通讯作者: Iida J.

前歯部交叉咬合自然発症マウス(BALB/c-bm/bm)の蝶後頭軟骨結合部の免疫組織学的検討

自发性前牙反颌小鼠蝶枕软骨连接处的免疫组织学检查（BALB/c-bm/bm）

• 发表时间: 2010
• 作者: 和田悟史;大西康友;菅原由紀;梶井貴史;塚本祐理;斎藤文男;平林義章;飯田順一郎
• 通讯作者: 飯田順一郎