International Collaboration Study on the Racial Difference in Coronary Vasospasm

冠状动脉痉挛种族差异的国际合作研究

基本信息

项目摘要

1. We have demonstrated that Rho-kinase is substantially involved in the molecular mechanism for coronary vasospasm.2. We have demonstrated that Rho-kinase is substantially involved in the molecular mechanism fornot only epicardial vasospasm but also microvascular vasospasm.3. We have demonstrated that long-term inhibition of Rho-kinase causes a regression of both coronary arteriosclerosis and coronary vasospasm.4. We have identified the novel SNP of Rho-kinase, G930T in its catalytic domain and have demonstrated that this SNP is associated with an enhancement of Rho-kinase activity.5. We have demonstrated that the frequency of the T930allele is significantly higher in patients with coronary vasospasm than in those without the spasm or controls. We have further demonstrated that this SNP is not noted in Caucasian patients with angina pectoris.6. Taken together, those results suggest that the relatively higher frequency of G930T could explain, at least in part, the racial difference in the prevalence of coronary vasospasm between Japanese and Caucasian populations.7. We have published the English review regarding the therapeutic importance of Rho-kinase.
1.我们已经证明Rho激酶在冠状动脉痉挛的分子机制中发挥着重要作用。2.我们已经证明Rho激酶不仅参与心外膜血管痉挛的分子机制,还参与微血管痉挛的分子机制。3.我们已经证明,长期抑制Rho激酶可以使冠状动脉硬化和冠状血管痉挛消退。4.我们在其催化结构域中鉴定了Rho激酶的新SNP,G930T,并证明该SNP与Rho激酶活性的增强有关。5.我们已经证明,患有冠状血管痉挛的患者中 T930 等位基因的频率显着高于没有痉挛的患者或对照组。我们进一步证明,在患有心绞痛的白种人患者中未发现该 SNP。6。总而言之,这些结果表明,G930T 相对较高的频率可以解释(至少部分解释)日本人和白种人之间冠状血管痉挛患病率的种族差异。7。我们已经发表了有关 Rho 激酶治疗重要性的英文评论。

项目成果

期刊论文数量(52)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Rho-kinase is an important therapeutic target in cardiovascular medicine. (Review)
Rho-激酶是心血管医学中的重要治疗靶点。
Rho-kinase is an important therapeutic target in cardiovascular medicine.
EBM循環器疾患の治療、冠攣縮性狭心症
EBM治疗心血管疾病、血管痉挛性心绞痛
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    伊藤昭;下川宏明
  • 通讯作者:
    下川宏明
Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries -Involvement of multiple mechanism
长期抑制Rho激酶抑制猪冠状动脉支架植入后新生内膜形成-多重机制参与
Beneficial effects of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia-reperfusion injury in canine coronary microcirculation in vivo.
羟基法舒地尔(一种特异性 Rho 激酶抑制剂)对体内犬冠状动脉微循环缺血再灌注损伤的有益作用。
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yada T;Shimokawa H;et al.
  • 通讯作者:
    et al.
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SHIMOKAWA Hiroaki其他文献

SHIMOKAWA Hiroaki的其他文献

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{{ truncateString('SHIMOKAWA Hiroaki', 18)}}的其他基金

The possibility of pleiotropic effects of Novel Oral Anticoagulants (NOAC) on Rho-kinase-cyclophilin A System
新型口服抗凝剂 (NOAC) 对 Rho-激酶-亲环素 A 系统多效作用的可能性
  • 批准号:
    25670379
  • 财政年份:
    2013
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
The role of SmgGDS in the pleiotropic effects by statins
SmgGDS 在他汀类药物多效性中的作用
  • 批准号:
    23659071
  • 财政年份:
    2011
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Molecular mechanisms for NOSs-mediated responses in microvessels
NOS介导的微血管反应的分子机制
  • 批准号:
    22390154
  • 财政年份:
    2010
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Experimental and Clinical Studies on the Significance of Endothelium-Derived Hyperpolarizing Factor (EDHF)
内皮源性超极化因子(EDHF)意义的实验和临床研究
  • 批准号:
    16209027
  • 财政年份:
    2004
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Development of Nanomedicine for the Treatment of Cardiovascular Diseases
开发治疗心血管疾病的纳米药物
  • 批准号:
    13557068
  • 财政年份:
    2001
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Role of Rho/Rho-kinase-mediated pathway in the pathogenesls of atherosclerosis
Rho/Rho激酶介导的通路在动脉粥样硬化发病机制中的作用
  • 批准号:
    13307024
  • 财政年份:
    2001
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Basic and clinical studies on the role of inflammatory mechanisms in the pathogenesis ischemic heart disease
炎症机制在缺血性心脏病发病机制中的基础与临床研究
  • 批准号:
    12470158
  • 财政年份:
    2000
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Development of Chronic Heart Failure Model Caused by Inflammatory Cytokines and Establishment of Prophylactic and Therapeutic Strategies for the Heart Failure
炎症细胞因子所致慢性心力衰竭模型的建立及心力衰竭防治策略的建立
  • 批准号:
    08557050
  • 财政年份:
    1996
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
The role of inflammatory mechanisms in the pathogenesis of ischemic heart disease. Basic and clinical studies.
炎症机制在缺血性心脏病发病机制中的作用。
  • 批准号:
    07457173
  • 财政年份:
    1995
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Role of Inflammatory Cytokines in the Development and Progression of Ischemic Heart Diseases-Experimental and Clinical Studies-
炎症细胞因子在缺血性心脏病发生和进展中的作用-实验和临床研究-
  • 批准号:
    05454274
  • 财政年份:
    1993
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)

相似海外基金

Exercise training for vasospastic angina
血管痉挛性心绞痛的运动训练
  • 批准号:
    19K11762
  • 财政年份:
    2019
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Explorateive research of biomarkers for coronary microvascular dysfunction in the patients with vasospastic angina
血管痉挛性心绞痛患者冠状动脉微血管功能障碍生物标志物的探索性研究
  • 批准号:
    16K09413
  • 财政年份:
    2016
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Identification of a new risk factor related to oxidative stress of vasospastic angina pectoris
鉴定与血管痉挛性心绞痛氧化应激相关的新危险因素
  • 批准号:
    15K09105
  • 财政年份:
    2015
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Circadian variation of Rho-kinase activity in circulating leukocytes of patients with vasospastic angina.
血管痉挛性心绞痛患者循环白细胞中 Rho 激酶活性的昼夜变化。
  • 批准号:
    25461038
  • 财政年份:
    2013
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Rho-kinase activity in circulating neutrophils as a useful biomarker for diagnosis and disease activity assessment of vasospastic angina
循环中性粒细胞中的 Rho 激酶活性作为血管痉挛性心绞痛诊断和疾病活动评估的有用生物标志物
  • 批准号:
    23591026
  • 财政年份:
    2011
  • 资助金额:
    $ 22.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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