Computational fluiddynamical analysis of correlations between blood flow and LDL at the vascular location where atherosclerosis occurs preferentially

动脉粥样硬化优先发生血管部位血流量与 LDL 相关性的计算流体动力学分析

• 批准号: 06680868
• 负责人: KAGIYAMA Mitsuyasu
• 金额: $ 1.41万
• 依托单位: Kawasaki College of Allied Health Professions
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06680868/
• 关键词: Numerical Fluiddynamics; Lattice Gas Automaton; Lattice Boltzman Equation; Blood Flow; 計算流体力学; 格子気体; 格子気体法; 格子ボルツマン方程式

The final goal of this study is to analyze the effects of the hemodynamics at the vascular locations where atherosclerosis occurs preferentially and mechanical properties of endthelial cells on and LDL through vessel walls using computational fluid mechanics. In the first year, a computer program simulating a blood flow by a lattice gas automaton (LGA) method was developed. In a LGA method, both space and time are descrete and particles move along links on a regular lattice and collide each other on each lattice site according to some properly desinged rules and conservation lows. Although the LGA method seems to offer a simple and efficient tool for simulating blood flows, it was difficult to achieve high accuracy with LGA because of its statistical noise according to the particle nature. In the second year we applied the lattice Boltzman equation (LBE) method for simulating blood flows. One advantage of the LBE method is the absence of the noise as described above. A computer program to solve numerically the LBE equation is developed and tested by applyng to two dimensional flow field Furthermore, a numerical analysis of blood flow at the aorto-renal bifurcations was carried out using computational fluiddynamics code alpha-flow based on finite difference methods. Numerical results were agreed with in-vivo data measured by 20Mhz ultrasound pulsed Doppler velocimeter.

本研究的最终目标是利用计算流体力学分析动脉粥样硬化优先发生的血管位置的血流动力学以及内皮细胞和低密度脂蛋白通过血管壁的机械特性的影响。第一年，开发了一种通过格子气体自动机（LGA）方法模拟血流的计算机程序。在 LGA 方法中，空间和时间都是离散的，粒子沿着规则晶格上的链接移动，并根据一些适当设计的规则和守恒低点在每个晶格位置上相互碰撞。尽管 LGA 方法似乎提供了一种简单而有效的模拟血流的工具，但由于其根据粒子性质的统计噪声，很难用 LGA 实现高精度。第二年我们应用格子玻尔兹曼方程（LBE）方法来模拟血流。 LBE 方法的优点之一是不存在如上所述的噪声。开发了一种用于数值求解 LBE 方程的计算机程序，并通过应用于二维流场进行了测试。此外，使用基于有限差分法的计算流体动力学代码 alpha-flow 对主动脉-肾分叉处的血流进行了数值分析。数值结果与 20Mhz 超声脉冲多普勒测速仪测量的体内数据一致。

项目成果

Matsumoto, T et al: "Evaluation of Spatial Control Unit for Regional Myocardial Blood Flow by a Molecular Flow Tracer" The 2nd World Congress of Biomechanics. Abstract. 1. 34-34 (1994)

Matsumoto, T 等人：“通过分子流示踪剂评估区域心肌血流的空间控制单元”第二届世界生物力学大会。

Mochizuki, S et al: "Effect of intramyocardial slosh phnomenon on the endothelial cell form of the coronary artery" World congress on medical physics and biomedical engineering. Proceedings. 201-201 (1994)

Mochizuki, S 等人：“心肌内晃动现象对冠状动脉内皮细胞形态的影响”世界医学物理和生物医学工程大会。

Seiichi Mochizuki他: "Effect of intra-myocardial slosh phenomenon on the endothelial cell form of the coronary artery" Proceedings of the World Congress on Medical Physics and Biomedical Engineering. 1. 201- (1994)

Seiichi Mochizuki 等人：“冠状动脉心肌内晃动现象对动脉内皮细胞形态的影响”世界医学物理和生物医学工程大会论文集 1. 201- (1994)。

Masami GOTO: "Observation of the thebesian vein and its outflow in the beating heart" J.Cardiovascular Diagnosis and Procedures. 12. 117 (1994)

Masami GOTO：“对跳动心脏中底比斯静脉及其流出的观察”J.心血管诊断和手术。

Mitsuyasu KAGIYA: "Analysis of the characteristics of blood flow patterns in arteries at the aorto-renal bifurcations using computational fluiddynamics (in Japanese)" 15th JCMI. 267 (1995)

Mitsuyasu KAGIYA：“使用计算流体动力学分析主动脉-肾分叉处动脉血流模式的特征（日语）”第 15 届 JCMI。