Regeneration of central and peripheral nerve after nerve anastomosis

神经吻合后中枢和周围神经的再生

• 批准号: 06671721
• 负责人: MURAKAMI Shingo
• 金额: $ 1.28万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671721/
• 关键词: Facial paralysis; Hypoglossal-Facial anastomosis; Accesory-Facial anastomosis; Nerve regeneration; HRP; 舌下神経-顔面神経吻合術; 顔面神経; 舌下神経; 神経吻合

To clarify the usefulness of hypoglossal-facial anastomosis and accessory-facial anastomosis for facial rehabilitation when the facial nerve is sacrificed. We carried out hypoglossal-facial anastomosis and accessory-facial anatomosis in guinea pigs using classic hypoglossal-facial anastomosis method and Y-shaped silicone tube. Data obtained from both blink reflex measurement and histological study demonstrate a good quality of regeneration of the facial nerve from the hypoglossal nerve completed 6 months after the operation. In addition a new nerve bundle was regenerated from the proximal stump of the facial nerve connecting to the anastomotic site in 80% of the animals. The diameter of regenerated nerve bundle and number of axon in the hypoglossal-facial anastomosis were significantly greater than those of accessory-facial anastomosis at both 4 and 8 weeks postoperation. The conduction velocity of the hypoglossal-facial anastomosis was also faster than that of accessory-facial anastomosis. These results suggest that hypoglossal-facial anastomosis is more favorable surgical choice for facial rehabilitation than accessory-facial anastomosis.

阐明舌下面部吻合术和副面部吻合术在面神经牺牲时的面部康复中的作用。我们采用经典的舌下面部吻合方法和Y形硅胶管对豚鼠进行舌下面部吻合和副面部解剖。从眨眼反射测量和组织学研究中获得的数据表明，术后 6 个月完成的舌下神经面神经再生质量良好。此外，80% 的动物从连接到吻合部位的面神经近端残端再生出新的神经束。术后4、8周舌下面部吻合术再生神经束直径和轴突数量均明显大于副面部吻合术。舌下面部吻合的传导速度也快于副面部吻合。这些结果表明，舌下面部吻合术比副面部吻合术对于面部康复来说是更有利的手术选择。

项目成果

Yuh-Shyang Chen: "Regeneration of facial nerve after hypoglossal facial anastomosis:an animal study." Otolaryngology Head and Neck Surgery. 111(6). 710-716 (1994)

Yuh-Shyang Chen：“舌下面部吻合术后面神经的再生：一项动物研究。”

Yuh-Shyang Chen: "Change in facial nerve innervation follpwing hypoglossal-facial anastomosis:an animal study." Acta Otolaryngol(Stockh). 114. 637-642 (1994)

Yuh-Shyang Chen：“舌下面部吻合术后面神经神经支配的变化：一项动物研究。”

Singo Murakami, Naoaki Yanagihara: "Degeneration and regeneration of neuromusclar junction in guinea pig mimic muscle, a scanning electron microscopic study." Eur Arch Otolaryngol. supple. S425-S427 (1994)

Singo Murakami、Naoaki Yanagihara：“豚鼠模拟肌肉神经肌肉接头的退化和再生，一项扫描电子显微镜研究。”

Shingo Murakami: "Degeneration and regeneration of neuromusclar junction in guinea pig mimic muscle," Eur Arch Otolaryngol. supple. S425-S427 (1994)

Shingo Murakami：“豚鼠模拟肌肉中神经肌肉接头的退化和再生”，Eur Arch Otolaryngol。

Tetsuo Kozawa: "Motor innervation pattern of the orbicularis oris muscle in guinea pig." Eur Arch Otolaryngol. supple. S380-S382 (1994)

Tetsuo Kozawa：“豚鼠口轮匝肌的运动神经支配模式。”