The role of humoral factors in the gastric hyperdynamic circulation of chronic portal hypertension

体液因素在慢性门脉高压胃高动力循环中的作用

• 批准号: 06671292
• 负责人: YOSHIDA Takanori
• 金额: $ 1.28万
• 依托单位: Oita Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671292/
• 关键词: portal hypertension; hyperdynamic state; glucagon

The role of glucagon as a mediator of gastric hyperdynamic circulation, induced by carbon tetrachloride (CCl_4), was assessed in cirrhotic rats. A selective elimination of pancreatic glucagon from the circulation was achieved by the intravenous infusion of a glucagon antiserum. Gastric blood flow was measured by laser-Doppler flowmetry. The glucagon antiserum had no effect on the blood flow in the stomach in control rats, while in cirrhotic portal hypertensive rats, the glucagon antiserum significantly reduced gastric blood flow (30%). The glucagon antiserum did not completely exclude the gastric hyperdynamic state in the cirrhotic rats. It would thus appear that glucagon contributes to a portion of the gastric hyperdynamic circulation associated with cirrhotic portal hypertension.

在肝硬化大鼠中评估了胰高血糖素作为四氯化碳 (CCl_4) 诱导的胃高动力循环介质的作用。通过静脉输注胰高血糖素抗血清实现了从循环中选择性消除胰腺胰高血糖素。通过激光多普勒流量计测量胃血流量。胰高血糖素抗血清对对照大鼠的胃血流量没有影响，而在肝硬化门脉高压大鼠中，胰高血糖素抗血清显着减少胃血流量（30%）。胰高血糖素抗血清并不能完全排除肝硬化大鼠的胃高动力状态。因此，看来胰高血糖素有助于与肝硬化门脉高压相关的胃高动力循环的一部分。

项目成果

Takanori Yoshida,et al: "The role of glucagon in the gastric hyperdynamic circulation of cirrhotic portal hyper teusive rats." Surg Today (Jpn J Surg). 25. 906-910 (1995)

Takanori Yoshida 等人：“胰高血糖素在肝硬化门静脉高压大鼠胃高动力循环中的作用。”