A New Drug Delivery System (DDS) Developement Using Plasma-Irradiated Pharmaceutical Aids

使用等离子体辐照药物辅助剂开发新的药物输送系统 (DDS)

基本信息

批准号：
04671327
负责人：
KUZUYA Masayuki
金额：
$ 1.28万
依托单位：
Gifu Pharmaceutical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

项目摘要

1. We have undertaken Ar plasma irradiation on a variety of synthetic polymers to explore the molecular mechanism of plasma treatment, and the redicals formed were studied by electron spin resonance (ESR) with the aid of systematic computer simulations. Through this research project, we have elucidated the nature of plasma-induced surface radicals of powdered polyethylene (PE), polycondensed polymer such as polycarbonate (PC) and myo-inositol for an initial study of various polycarbohydrate radicals.2. The dissolution profiles of plasma-irradiated double-compressed tablets prepared from a thephylline tablet as a core material and PC powder as a single wall material can be varied so as to allow release of the drug at different rates, depending on the set of conditions chosen for tablet manufacturing and plasma operational conditions.3. The plasma-irradiated couble-compressed tablets consisting of poy-DL-latic acid (PLA) and polyoxymethylene (POM) as the outer layr can be applied to an implantable dosage form in the subcutaneous tissue.4. The dissolution profiles of the plasma-irradiated double-compressed tablets with the outer layr consisting of a degradable polymer possessing a crosslinkable side chain (benzylmethacrylate and methylmethacrylate copolymer) depends on not only plasma operational conditions but also the copolymer composition.5. It was found that the mechanical vibration of the plasma-irradiated PE caused the radical recombination reaction resulting in the interlinking between the paricles. Thus, the dissolution profile of the comosite powder prepared by the mechanical vibration of the plasma-irradiated PE and theophylline is controlled by the radical concentration of the plasma-irradiated PE.It is hoped that further devices applicable to a wide range of drugs and polymers will be developed in the course of work now in progress to examine the usefulness of plasma-irradiation of DDS fabrications.

1。我们已经对各种合成聚合物进行了AR血浆辐照，以探索血浆处理的分子机制，并通过系统的计算机模拟研究了电子旋转共振（ESR）形成的重复。通过该研究项目，我们阐明了血浆诱导的聚乙烯（PE），聚合碳的聚合物（例如聚碳酸酯（PC）和肌醇）的性质，以对各种多碳水化合物自由基进行初步研究。2。血浆辐射的双压缩片剂的溶解曲线由phylline片剂作为核心材料和PC粉制备为单个壁材料，以便以不同的速度释放该药物，取决于选择的条件。用于平板电脑制造和等离子体操作条件3。由POY-DL-LATIC酸（PLA）和聚氧甲基（POM）组成的血浆辐射的couble片片剂可以将其用于皮下组织中的植入剂量形式。4。血浆辐射的双压缩片剂的溶解轮廓，外层由具有可降解的聚合物组成，该聚合物具有可连接的侧链（苄基甲基丙烯酸酯和甲基甲基丙烯酸酯共聚物），这不仅取决于等离子体的操作条件，还取决于共聚条件，还取决于共聚物的组成。5。发现血浆辐射的PE的机械振动导致根治性重组反应导致片段之间的相互联系。因此，通过等离子体辐射的PE和茶碱的机械振动制备的复合粉末的溶出度受到血浆辐照PE的根部浓度的控制。现在将在正在进行的工作过程中开发，以检查DDS制造的血浆辐射的有用性。