New Chiral Synthons from Glcidol and their Applications to Natural Products Synthesis.

缩水甘油的新型手性合成子及其在天然产物合成中的应用。

• 批准号: 04640533
• 负责人: KATSUMURA Shigeo
• 金额: $ 1.34万
• 依托单位: Kwansei Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04640533/
• 关键词: (R)-Glycidol; Threoninol; Hydroxyphenylalaninol; Sphingoshine; Phospholipase A2; Stereoselectiv Synthesis; New lnhibitor; Oxazoline Phospholipid; 両異性体; キラル補助剤; 不斉アルドール反応; グリシドール; オキサゾリジノン誘導体; キラルな合成シントン; ホスホリパーゼA_2阻害; リン脂質類縁体

Syntheses of all stereoisomers of threoninol and hydroxyphenylalaninol from (R)-glycidol via an oxazolidinone derivative werer established. As a further application, stereoselective synthesis of sphinfoshine wes realized. A new phospholipase A2 inhibtitor, oxazolidinone phospholipid was also synthesized.

来自（R） - 糖醇的所有立体异构体的合成。作为进一步的应用，实现了狮身人面像的立体选择合成。还合成了一种新的磷脂酶A2抑制剂，黄唑啉酮磷脂。

项目成果

S.Katsumura: "Diastereoselective Synthesis of gamma-Hydroxy-beta-amino Alcohols,(2S,3S)-and(2S,3R)-Threoninol and-Hydroxyphenylalaninol,from(R)-Glycidol" Tetrahedron:Asymmetry. 5,(in press). (1994)

S.Katsumura：“从(R)-缩水甘油非对映选择性合成γ-羟基-β-氨基醇、(2S,3S)-和(2S,3R)-苏氨醇和-羟基苯丙氨醇”四面体：不对称性。

S.Iwama: "A New Inhibitor of Phosholipase A2" Synthesis and Inhibition Mechanism of Oxazolidinone Phospholipid, Tetrahedron. (to be submitted.).

S.Iwama：“一种新型磷脂酶A2抑制剂”恶唑烷酮磷脂四面体的合成和抑制机制。

S.Katsumura: "Diastereoselective Synthesis of g-Hydroxy-b-amino Alcohols, Threoninol and Hydroxyphenylalaninol from (R)-Glycidol" Tetrahedron : Asymmetry. 5. 161-164 (1994)

S.Katsumura：“从 (R)-缩水甘油中非对映选择性合成 g-羟基-b-氨基醇、苏氨醇和羟基苯丙氨醇”四面体：不对称性。

S.Iwama: "A New Route for Protected Amino Alcohols from(R)-Glycidol" Bull.Chem.Soc.Jpn.(to be submitted).

S.Iwama：“从(R)-缩水甘油制备受保护的氨基醇的新路线”Bull.Chem.Soc.Jpn.（待提交）。

S.Iwama: "A New Inhibitor of Phospholipase A2:Synthesis and Inhibition Mechanism of Oxazolidinone Phospholipid" Tetrahedron. (to be submitted).

S.Iwama：“一种新型磷脂酶A2抑制剂：恶唑烷酮磷脂的合成和抑制机制”四面体。