A study on a development of a retinal lattice degeneration

视网膜格子变性发展的研究

• 批准号: 03807117
• 负责人: SAKATA Hiroshi
• 金额: $ 1.15万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03807117/
• 关键词: Superior oblique muscle; Lattice degeneration; 上斜筋牽引

1. Materials and MethodsA tendon of superior oblique muscle (SOM) was exposed, and looped by a 4-0 silk thread in a newborn rabbit. The silk thread was connected with a 2-0 nylon from a handmade vibrator which worked by a magnetic morter. A contraction of SOM forced on hour everyday during a various period (1 to 3 months). An eye ball was enucleated after a non-stimulated period (2 to 3 months), and macroscopically or microscopically observed.2. Result(1) macroscopic findings : A retina below the insertion of SOM to a sclera showed a slightly diffuse discoloration, compared to a control, at 2 to 3 months.(2) microscopic findings : A choroid adjacent to the insertion of SOM to a sclera had a strong edema at 2 months, and a slight atrophy at 3 months. A sclera was thickened, and the collagen fibers was irregularly arranged. But an architecture of the retina was normal at all the time.3. A further perspectionBased upon histological changes in the present study and a known physiological role of a choroid in a maintenance of retinal architecture and function, there is a high possibility that a retina may, in the future, develop a histological change like a lattice degeneration or something in these rabbit in which SOM was forced.

1。露出上倾斜肌肉（SOM）的材料和方法肌腱，并在新生兔中以4-0的丝线循环。丝线与手工振动器的2-0尼龙连接，该振动器由磁性变速器起作用。在不同时期（1至3个月），每天都会每天强迫SOM收缩。在未刺激的周期（2至3个月）之后，将眼球摘除，并在宏观上或显微镜下观察到2。结果（1）宏观发现：与对照组相比，在2到3个月时，SOM插入巩膜下方的视网膜显示出略有散布的变色。（2）微观发现：与SOM插入到A的脉络膜相邻巩膜在2个月时具有强烈的水肿，并且在3个月时有轻微的萎缩。巩膜变稠，胶原蛋白纤维不规则排列。但是视网膜的建筑一直是正常的。3。基于本研究的组织学变化以及脉络膜在维持视网膜结构和功能中的已知生理作用的进一步观点，很可能将来，视网膜可能会发展出诸如晶格退化或诸如晶格退化或之类的组织学变化在这些兔子中，索姆被迫的东西。

项目成果

坂田広志・調枝寛治: "網膜格子状変性の成因についての一試案" 眼科臨床医報.85. 1760-1760 (1991)

Hiroshi Sakata 和 Hiroharu Choeda：“视网膜格子变性原因的初步建议”眼科临床杂志.85 1760-1760（1991）。

Hiroshi Sakata: "A tentative plan about development of retinal lattice degeneration" Japanese Review of Clinical Ophthalmdogy. Vol.85. 1760-1760 (1991)

Hiroshi Sakata：“关于视网膜格子变性发展的初步计划”日本临床眼科评论。