A Study of Super-selective Hyperthermia Using Dextran Magnetite Particles

右旋糖酐磁铁矿颗粒超选择性热疗的研究

基本信息

批准号：
03454299
负责人：
TAZAWA Kenji
金额：
$ 3.78万
依托单位：
Toyama Medical & Pharmaceutical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454299/
关键词：
Inductive Heating RF Heating Super-selective Hyperthermia Implant Heating Combined Therapy Dextran Magnetite Particles VX-2 Tumor Meth-A Tumor デキストラン複合磁性体 500kHz帯誘導加温法微小励起物質 VX2腫瘍細胞管腔臓器腫瘍モデル VZ2腫瘍細胞

项目摘要

Hyperthermia is using clinically as the 5th treatment for cancer. But, it is difficult to heat cancer cells selectively. When heating deep seated tumors, it is difficult to identify the heated area and ignore damage for normal tissues. In previous study, we have reported selective hyperthermia using dextran magnetite particles (DM) and inductive heating method. In this study, a conversion of heating unit and some studies were investigated for clinical use (as follows).1) The power of heating unit has been increased to use clinically. The system has been set up to regulate automatically the temperature by a computer.2) The deep seated tumors of New Zealand white rabbits were established with VX-2 tumors (ex. liver, colon, and urinary bladder tumor). These tumors were heated by DM particles and inductive heating unit. The methods of heating were intratumorous injection method, balloon method, and intracavitary method. The inhibition of tumor proliferation was investigated in liver and urinary bladder tumor.3) Meth-A tumors of BALB/c mice were heated by combination with anticancer drug (MMC). The increased life span after treatment were observed in the group of hyperthermia and MMC.4) A new heating method with tubular implants were designed to heat deep seated tumor. The implants were polyester tube and filled up with DM aqueous sol. The temperature of an phantom with implants was measured in the inductive field. An area of 20 x 20 mm was heated with changing of power, number of implants, and arrangement.The selective heating of cancer was expected with use of the inductive heating at 500 kHx and DM particles. The possibility is expected of an application for the treatment of various cancer.

热疗在临床上用作癌症的第五疗法。但是，很难有选择地加热癌细胞。当加热深座肿瘤时，很难识别加热区域并忽略正常组织的损害。在先前的研究中，我们报道了使用右旋磁铁矿颗粒（DM）和电感加热方法的选择性高温。在这项研究中，对加热单元的转化和一些研究进行了研究（如下）。1）加热单元的功率已增加以在临床上使用。该系统已建立以通过计算机自动调节温度。2）使用VX-2肿瘤（例如肝脏，结肠和膀胱肿瘤）建立了新西兰白兔子的深座肿瘤。这些肿瘤是通过DM颗粒和电感加热单元加热的。加热方法是肿瘤内注射方法，气球方法和腔内方法。研究了肿瘤增殖的抑制作用，在肝脏和膀胱肿瘤中进行了抑制。3）BALB/C小鼠的METH-A-A肿瘤通过与抗癌药物（MMC）结合加热。在高温和MMC组中观察到治疗后的寿命增加。4）一种使用管状植入物的新加热方法设计为加热深座肿瘤。植入物是聚酯管，并用DM水溶液填充。在电感场中测量了带有植入物的幻影的温度。通过更换功率，植入物数量和排列加热20 x 20 mm的面积。通过使用500 kHx和DM颗粒的电感加热，预计癌症的选择性加热。预期可以应用各种癌症的可能性。