Relationship between aging, muscle metabolisn and excercisp training by MRS

MRS研究衰老、肌肉代谢和运动训练之间的关系

• 批准号: 01480269
• 负责人: MATSUMOTO K.
• 金额: $ 3.07万
• 依托单位: Institute of Clinical Medicine, University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01480269/
• 关键词: NMR; muscle metabolism; endurance training; aging; Aging; exercise physiology; ^<31>PNMR; muscle energetics; ^<31>P NMR; training; Sports medicine

To evaluate changes in muscle energetics following endurance training, we measured phosphorus -31 nuclear magnetic resonance ( ^<31>P NMR) spectra on rat muscle in vivo before and after training in the same animals. The endurance training was performed in the training group for 3 months. ^<31>P NMR spectra were obtained serially at rest, during exercise by electric stimulation, and during recovery. Intramuscular phosphocreatine (PCr), inorganic phosphate (Pi), ATP and pH were determined from the NMR spectra. The ratio of PCr/ (PCr+Pi) at rest showed no difference between the training and control group even after 3 months of training. During exercise, however, this ratio was significantly higher in the training group than in the control group. The ratio also recovered more rapidly after exercise in the training group. The muscular pH slightly decreased - 0.1 pH unit during exercise, but did not show significant difference in both groups. These results indicate that the endurance training of 3 months improves the ATP supply system in the muscle without significant change in the muscular fiber types. It is also demonstrated that ^<31>P NMR is a potent method to evaluate the training effects on the same individuals consecutively.

为了评估耐力训练后肌肉能量的变化，我们测量了磷-31核磁共振（ ^<31> p NMR）在体内的大鼠肌肉光谱（ ^<31> p NMR）光谱前后，在同一动物中训练之前和之后。耐力训练在训练小组中进行了3个月。 ^<31> p NMR光谱在静止时，在静止期间通过电刺激和恢复过程获得。从NMR光谱确定肌肉内磷酸盐（PCR），无机磷酸盐（PI），ATP和pH。即使经过3个月的训练，PCR/（PCR+PI）的静止之比也没有训练组和对照组之间的差异。但是，在锻炼过程中，训练组的该比率显着高于对照组。训练组运动后，该比率也更快地恢复。肌肉pH值略有下降-0.1 pH单位在运动过程中，但两组的差异没有显着差异。这些结果表明，3个月的耐力训练可改善肌肉中的ATP供应系统，而肌肉纤维类型没有显着变化。还证明 ^<31> p NMR是连续评估同一个人的训练效果的有效方法。

项目成果

久野譜也: "^<31>P NMRによるラット骨格筋のエネルギ-代謝機能の評価" 日本磁気共鳴医学会雑誌. 10. 263 (1990)

Fuya Kuno：“通过 31 P NMR 评估大鼠骨骼肌的能量代谢功能”日本医学磁共振学会杂志 10. 263 (1990)。

Shin-ya Kuno et al.: "Evaluation of exercise muscle energetics by NMR" Ann. Physiol. Anthrop. 9. 235-239 (1990)

Shin-ya Kuno 等人：“通过 NMR 评估运动肌肉能量”Ann。

久野 譜也他: "バイオメカニクス研究1990( ^<31>PNMRによる高年齢者の筋エネルギ-代謝)" 日本バイオメカニクス学会編、メディカルプレス, 8 (1990)

Fuya Kuno 等：《Biomechanics Research 1990（^<31>使用 PNMR 的老年人肌肉能量代谢）》，日本生物力学会编，医学出版社，8（1990）

Shin-ya Kuno et al.: " ^<31>PNMR study on the effects of endurance training" Eur. J. Appl. Physiol.

Shin-ya Kuno 等人：“^<31>PNMR 对耐力训练效果的研究”Eur。

Kuno,S.et al: "Evaluation of exercise muscle energetics by NMR" Ann.Physiol.Antrop.9. 235-239 (1990)

Kuno,S.et al：“通过 NMR 评估运动肌肉能量”Ann.Physiol.Antrop.9。