Depth Selective Photoplethysmography-based Method for Pulse Transit Time Measurement at a Single Measuring Position (DeePPG)

基于深度选择性光电容积描记法的单一测量位置脉冲传输时间测量方法 (DeePPG)

• 批准号: 429529735
• 负责人: Professor Dr. Anton Grabmaier
• 金额: --
• 依托单位: Fachgebiet Elektronische Bauelemente und Schaltungen (EBS)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/429529735?language=en
• 关键词: Depth; Selective; Photoplethysmography; based; Method

The Pulse Transit Time (PTT) is a cardiovascular parameter used in various medical applications. The most challenging is currently the application of cuff-less blood pressure measurement. The established method for measuring PTT is based on the combination of electrocardiography (ECG) and photoplethysmography (PPG). It measures the time difference between the electrical excitation of the heart (ECG) and the arrival of the (blood) pulse wave caused by the heart contraction at a perfused skin area (PPG). This requires several distributed measuring points on the body and thus a prior preparation of the subject. The PPG is an optical method which enables the measurement of blood and blood flow parameters in the skin through the combination of an optical transmitter and an optical receiver. In this project, this method should be further developed in such a way that a local PTT can be recorded at a single measuring position. Thereby, the usage of an ECG is not required. For this purpose, the layer structure of the skin and the wavelength dependence of the optical properties of blood and tissue are used. Investigations should show whether a depth-selective PPG method can be developed by parallel measurement with different wavelengths. With this depth selectivity, the pulse wave propagation perpendicular to the skin surface shall be analyzed and a local PTT determined. For this purpose, the physiological-physical relationships are dynamically simulated on the basis of a model of the microcirculation of the skin and correlated with real measurements. For the simulation, a one-dimensional optical model of the skin is to be combined with the pulse wave propagation modulated by the conduction theory. Thereby, a dynamic simulation of the optical interaction in the measuring volume becomes possible. To validate the simulation results, a measuring device should be developed which takes the special boundary conditions (e.g. the inhomogeneous structure of the skin) into account. Based on the knowledge gained in this way, a method will be developed which enables the measurement of PTT at only one measuring position on the body. Finally, the correlation with the new method will be validated on the basis of established reference measurement methods.

脉冲运输时间（PTT）是用于各种医疗应用中的心血管参数。目前最具挑战性的是应用无袖子血压测量。测量PTT的既定方法基于心电图（ECG）和光摄影学（PPG）的组合。它衡量心脏（ECG）的电激发与（血液）脉冲波的到来之间由灌注皮肤区域（PPG）引起的（血液）脉冲波的到来之间的时间差。这需要身体上的几个分布式测量点，因此需要对受试者的事先准备。 PPG是一种光学方法，可以通过光学发射器和光学接收器的组合来测量皮肤中的血液和血流参数。在此项目中，应以一种可以在单个测量位置记录本地PTT的方式进一步开发此方法。因此，不需要使用ECG。为此，使用了皮肤的层结构以及血液和组织光学特性的波长依赖性。研究应表明是否可以通过具有不同波长的平行测量来开发深度选择性的PPG方法。有了这种深度选择性，应分析垂直于皮肤表面的脉冲波传播并确定局部PTT。为此，根据皮肤的微循环模型，会动态模拟生理 - 物理关系，并与实际测量相关。对于模拟，皮肤的一维光学模型将与传导理论调节的脉搏波传播结合。因此，对测量体积中的光学相互作用进行动态模拟可能是可能的。为了验证仿真结果，应开发一个测量设备，以考虑特殊的边界条件（例如，皮肤的不均匀结构）。基于以这种方式获得的知识，将开发一种方法，该方法仅在一个测量身体上的一个测量位置就可以测量PTT。最后，将根据已建立的参考测量方法验证与新方法的相关性。