Project EpistemologyProduction of Knowledge between Contingency and Disposition using the example of CollaborativeResearch

项目认识论使用协作研究的例子在偶然性和处置之间产生知识

• 批准号: 423225684
• 负责人: Thomas Krämer
• 金额: --
• 依托单位国家: 德国
• 项目类别: Publication Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/423225684?language=en
• 关键词: Project; EpistemologyProduction; Knowledge; between; Contingency

The study draws up a methodological synopsis of concepts from Science Studies and New Materialism, in order to conceptualize collaborative research as an own field of research using the example of three cardiovascular Collaborative Research Centres (CRC) in Düsseldorf between 1968 and 2012 - among others with authors like Bachelard/Heidegger, Canguilhem, Latour, Rheinberger, Keating/Cambrosio. Along the lines of tension between institutional and methodological platforms (dispositions) and unpredictable results during the conduction of the CRCs (contingencies), the first chapter establishes a "project epistemology" which assumes that science does not discover but produces mutable drafts. With Bachelard, scientific projects are understood as dynamic intermediate spaces between the researching subject and the knowledge object to be produced in the research process, together with its instrumental-pictorial representations. With Latour translation chains are conveyed from the matter of the organism to the form of inscriptions in the life sciences. Epistemic things and technical objects in experimental systems (Rheinberger) are identified with CRCspecific experimental contingencies and institutional dispositions. The presentation of institutional history and clinical research at the Düsseldorf site is based on the platform concept of Keating/Cambrosio. In the second chapter, the local dispositions of the scientific and medical history of the hospital are clarified, which allowed to set up the first cardiovascular CRC 30 (1968-1985) in Düsseldorf. The analysis of the archive documents of the CRC 30 shows the historical-contingent initiation phase of the CRC funding program, the resonances between the optimization of the DFG Rules of Procedure and the development of cooperation structures as well as the research program of the CRC 30. Based on the presentation of the methodological spectrum of experimental cardiology, the second chapter concludes with the characterization of "translational gaps" - i.e. physiological incomparabilities between animal models and the clinical situation in humans. As a result, cardiovascular collaborative research focuses on the oscillation between holistic pathophysiological perspectives of clinicians and the reductive molecular biology perspectives of natural scientists: a CRC must translate these perspectives into a common problem horizon and bring them into synopsis for further research applications. DFG-Vordojck 54.011 - 03/18 Seite 4 von 8 Whether the laboratory mouse has the potential to close these translational gaps and act as a bridge between laboratory and clinic is answered in the third chapter. The study focuses on the transgenic mouse models used in CRC 612 (2002-2012). As hybrids between epistemic things and technical objects, the mice display their own possibilities due to their experimental materiality and resistance and change the understanding of normal and pathological of the CRC researchers.

The study draws up a methodological synopsis of concepts from Science Studies and New Materialism, in order to conceptualize collaborative research as an own field of research using the example of three cardiovascular Collaborative Research Centres (CRC) in Düsseldorf between 1968 and 2012 - among others with authors like Bachelard/Heidegger, Canguilhem, Latour, Rheinberger, Keating/Cambrosio.沿着制度和方法论平台之间的紧张关系（处置）和在传导CRC（意外情况）期间的不可预测的结果，第一章建立了一种“项目认识论”，假设科学没有发现，但会产生可变的草稿。借助Bachelard，科学项目被理解为研究主题与研究过程中要产生的知识对象之间的动态中间空间，以及其乐器图表。用拉图尔翻译链从生物体的问题传达到生命科学中的铭文形式。通过CRCSpecific实验意外事件和机构处置，可以确定实验系统（Rheinberger）中的认知事物和技术对象。杜塞尔多夫站点的制度历史和临床研究的介绍基于基廷/剑桥的平台概念。在第二章中，澄清了医院科学和病史的当地性格，允许在杜塞尔多夫建立第一个心血管CRC 30（1968-1985）。对CRC 30的档案文档的分析显示了CRC资金计划的历史倡议阶段，DFG程序的优化与CRC 30的合作规则的优化与CRC 30的研究计划之间的共鸣以及基于实验心脏病学的方法论的呈现，第二章的结论，CRC 30的研究计划。动物模型和人类的临床状况。结果，心血管协作研究的重点是临床医生的整体病理生理学观点与降低的自然科学家分子生物学观点之间的振荡：CRC必须将这些观点转化为一个共同的问题地平线，并将它们带入概要进行进一步研究应用中。 DFG -VORDOJCK 54.011-03/18 SEITE 4 VON 8实验室小鼠是否有可能缩小这些翻译间隙并充当实验室和诊所之间的桥梁，在第三章中回答。该研究的重点是CRC 612（2002-2012）中使用的转基因小鼠模型。作为认知事物和技术对象之间的杂种，小鼠由于自身的实验重要性和抵抗力而表现出自己的潜力，并改变了对CRC研究人员正常和病理学的理解。