Development of a new compact centrifugal blood pump system for extracorporeal circulation and its application

新型紧凑型体外循环离心血泵系统的研制及应用

基本信息

批准号：
61870054
负责人：
KAMIYA Akira
金额：
$ 2.82万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1987
项目状态：
已结题

项目摘要

A new compact centrifugal blood pump system for use for cardiac-assisted circuration has been developed by the project members in the first poject year: The impeller of the pump was connected directly to a miniature DC serevomotor by using a simple-gear coupling. Either pulsatile or nonpulsatile flow was produced by controlling the cuttent supply to the motor. Through in vitro tests, the pump characteristics and the degree of hemolysis were evaluated with regard of the configuration of the casing and the impeller. In accordance with the project grograms. the following results have been obtained.1. The semi-open type impeller having the blade angles at the inlet of 20゜and at the outlet of 50゜was the most appropriate a blood pump.2. The pumpgin capacity and the degree of hemolysis produced by the pump with volute casing were significatly improved at high flow rate region compared with those by the pump without volute casing.In the second project year, to analyse myocardial adaptive change of the nucleic acid metabolism in response to the prolonged left ventrecular (LV) pressure load reduction, LV to aorta bypass experiments were carried out in mongrel dogs using the newly developed system. After 10 hours bypadd with 50 - 80 % reduction compared with the control level of the peak-LV pressure, RNA polymerase activity was measured in purified nuclear preparation from left and right ventricular muscles. The of RNA polymerase activity of left to right ventricular muscule showed to decrease as compared with those of the control group. From thies result, it is suggested that the myocardial nucleic acid metabolism change following pressure load reduction would be originated without so much long period of time, and that the myocardial adaptive change would progress an opposite way against the cardiac hypertrophy process.The whole programs of this project were completed in this year with satisfactory results as described above.

项目成员在第一年的一年中已经开发了一种新的紧凑型离心泵系统，用于心脏辅助圆圈：泵的叶轮通过使用简单的胶合耦合直接连接到微型DC Serevomotor。通过控制电动机的切碎供应来产生脉冲或非脉冲流。通过体外测试，对壳体和叶轮的构型评估了泵的特性和溶血程度。按照项目的收集图。已经获得以下结果。1。半开放的叶轮具有20゜的入口，在50゜的出口处是最合适的血液泵。2。 The pumpgin capacity and the degree of hemolysis produced by the pump with volute casing were significantly improved at high flow rate region compared with those by the pump without volute casing.In the second project year, to analyse myocardial Adaptive change of the nuclear acid metabolism in response to the prolonged left ventrecular (LV) pressure load reduction, LV to aorta bypass experiments were carried out in mongrel dogs using the newly developed system.与峰值LV压力的对照水平相比，在10小时降低50-80％的BYPADD后，RNA聚合酶活性在从左侧和右心室肌肉中纯化的核制剂中测量。与对照组相比，左心肌的RNA聚合酶活性显示为减小。从此结果，建议降低压力载荷后的心肌核酸代谢变化将在没有太长时间的情况下起源，并且心肌适应性变化将以相反的方式与心脏肥大过程相反。