Development of highly sensitive MR molecular imaging method for early diagnosis and monitoring of Alzheimer disease

开发用于阿尔茨海默病早期诊断和监测的高灵敏度MR分子成像方法

• 批准号: 24659567
• 负责人: TOGAO Osamu
• 金额: $ 2.41万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659567/
• 关键词: 磁気共鳴画像（MRI）; アルツハイマー病; 造影剤; 早期診断; 分子イメージング; MRI; ミクログリア; アミロイドベータ; alzheimer disease

Recent study suggested that impared cognitive function observed in Alzheimer disease (AD) is related to microglia activations evoked by amyloid deposition in the brain. In this study, we have develop the novel MR molecular imaging method to detect microglia accumulation in the brain tissue by using Ultrasmall super paramagnetic iron oxide (USPIO) contrast agent. We confirmed in the animal model of AD that this technique could sensitively detect the USPIO phagocytized by microglia in the brain. In the future, this method can be a useful and sensitive method for early diagnosis and monitoring of AD in the clinical settings.

最近的研究表明，阿尔茨海默病（AD）中观察到的认知功能受损与大脑中淀粉样蛋白沉积引起的小胶质细胞激活有关。在这项研究中，我们开发了一种新颖的磁共振分子成像方法，通过使用超小超顺磁性氧化铁（USPIO）造影剂来检测脑组织中小胶质细胞的积累。我们在AD动物模型中证实，该技术可以灵敏地检测到大脑中小胶质细胞吞噬的USPIO。将来，该方法可能成为临床环境中 AD 早期诊断和监测的有用且灵敏的方法。