Acridine orange photodynamic antimicrobial chemotherapy for drug resistant bacterias

吖啶橙光动力抗菌化疗治疗耐药菌

• 批准号: 24659284
• 负责人: TSUNODA Ryu
• 金额: $ 2万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659284/
• 关键词: 光線力学療法; アクリジンオレンジ; 感染症; 感染制御; 耐性菌感染; 光感受性物質

The effect of acridine orange photodynamic antimicrobial chemotherapy for drug resistant bacterias was examined.Growth was significantly suppressed at 50 microgram/ml of acridine orange solution in Acinetobacter, vancomycin-resistant enterococci, enterococci, methicillin-resistant Staphylococcus aureus, Staphylococcus aureus, the growth rate was 4%, 17%, 18%, 7%, and 15% respectively.It was not revealed mechanism of growth inhibition of bacteria by the present method. Since the relatively strong growth inhibitory effect was observed against methicillin-resistant Staphylococcus aureus ,I was considered that acridine orange photodynamic antimicrobial chemotherapy was also possible clinical application in infection of bone and soft tissue.

考察吖啶橙光动力抗菌化疗对耐药菌的作用。50微克/ml吖啶橙溶液对不动杆菌、耐万古霉素肠球菌、肠球菌、耐甲氧西林金黄色葡萄球菌、金黄色葡萄球菌的生长有显着抑制作用，生长速度分别为 4%、17%、18%、7% 和 15%。没有揭示本方法抑制细菌生长的机制。由于对耐甲氧西林金黄色葡萄球菌有较强的生长抑制作用，因此认为吖啶橙光动力抗菌化疗在骨和软组织感染方面也有可能临床应用。

项目成果

アクリジンオレンジ光線力学療法による新しい感染症治療法の検討

研究使用吖啶橙光动力疗法治疗传染病的新方法

• 发表时间: 2014
• 作者: 角田隆

アクリジンオレンジ光線力学療法の感染症治療への応用

吖啶橙光动力疗法在感染性疾病治疗中的应用

• 发表时间: 2012
• 作者: 角田隆;角田隆;角田隆;角田隆
• 通讯作者: 角田隆