Exploring a exercise method to induce brain-derived neurotrophic factor more effectively.

探索更有效诱导脑源性神经营养因子的运动方法。

• 批准号: 24650322
• 负责人: KANEKO Fuminari
• 金额: $ 2.5万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24650322/
• 关键词: リハビリテーション; 電気刺激; 神経科学; 神経栄養因子; 運動

The present experiment was designed to clarify if the muscular contraction induced by the neuromuscular electrical stimulation (NMES) was effective to produce Brain-derived neurotrophic factor (BDNF) with comparing to voluntary muscular contraction. Healthy normal subjects participated in this study. After preliminarily executed trial experiments, the blood lactate, RER, VE, and serum BDNF concentration during and after exercise were measured and analyzed. Still more subjects were needed to conclude the effect of NMES on BDNF production, upward tendency of serum BDNF concentration during exercise was shown with compared to another condition (voluntary exercise, and sham stimulation).

设计本实验以阐明神经肌肉电刺激（NMES）诱导的肌肉收缩是否有效地产生脑源性的神经营养因子（BDNF），与自愿性肌肉收缩相比。健康的正常受试者参加了这项研究。初步执行试验实验后，测量和分析了在运动过程中和运动后血液乳酸，RER，VE和血清BDNF浓度。与另一种状况（自愿运动和假刺激）相比，还表明需要更多的受试者来结论NME对BDNF产生的影响，运动过程中血清BDNF浓度的向上趋势。

项目成果

Time couse changes of trunk muscle activities during sitting in a stable or unstable position

稳定或不稳定坐姿时躯干肌肉活动的时间变化

• 发表时间: 2012
• 作者: Hayami;T.;Kaneko;F.;et. al.
• 通讯作者: et. al.

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神経筋電気刺激の最大刺激強度と漸増時間が筋収縮による関節トルクに及ぼす影響

神经肌肉电刺激最大刺激强度和斜坡上升时间对肌肉收缩引起的关节扭矩的影响

• 发表时间: 2012
• 作者: 竹中 菜々, 川端 佑果;永田 浩三, 鳥橋 茂子;榊善成，金子文成，他
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脳機能を理解するための基礎知識

了解大脑功能的基础知识

• 发表时间: 2013
• 作者: Matsumoto Y;Miyazato M;Yokoyama H;Kita M;Hirao Y;Chancellor MB;Yoshimura N.;金子文成
• 通讯作者: 金子文成