The involvement of Streptococcus anginosus infection and AID expression in oral cancers

咽峡炎链球菌感染及AID表达与口腔癌的关系

• 批准号: 23659861
• 负责人: KODAMA YOSHITOYO
• 金额: $ 2.5万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659861/
• 关键词: 感染発癌; AID; 口腔細菌; 口腔癌; Streptococcus anginosus; 炎症; S. anginosus; 歯肉上皮細胞; 口腔レンサ球菌

Streptococcus anginosus infection could be closely related with oral squamous cellcarcinoma. Recent studies suggested that the aberrant expression of AID in the epithelial cells could re-sult in the generation of nucleotide alterations in tumor-related genes and possible malignant transforma-tion of the AID-expressing cells. In this study, the involvement of S. anginosus infection and the AID ex-pression in oral cancers was assessed. S. anginosus DNA was frequently detected in the oral squamous cell carcinoma, and the relatively higher AID expressions were observed in the cancerous region. The stimula- tion with S. anginosus antigens could induce the NF-kB activation and AID expression in cultured cell li- nes. Taken together, S. anginosus infection could be closely related with the AID expression in the oral squamous cell carcinoma.

动脉链球菌感染可能与口服鳞状细胞癌密切相关。 最近的研究表明，上皮细胞中辅助的异常表达可能会在肿瘤相关基因的核苷酸改变以及表达辅助细胞的恶性转化中的产生。在这项研究中，评估了弧菌感染链球菌感染和口服癌症的辅助剂的参与。在口服鳞状细胞癌中经常检测到Anginosus DNA，并且在癌区域观察到相对较高的AID表达。用弧菌抗原的刺激可以诱导培养的细胞液体中NF-KB激活和帮助表达。综上所述，链球菌感染可能与口腔鳞状细胞癌中的辅助表达密切相关。

项目成果

Subcutaneous Tissue Reactions Against Nano-apatite Collagen Composites

• DOI: 10.11344/nano.4.118
• 发表时间: 2012
• 期刊: Nano Biomedicine
• 作者: Wataru Hatakeyama;M. Taira;Hidemichi Kihara;M. Sasaki;S. Kimura;H. Kondo

Nested PCR を用いた小児口腔へのPorphyromonas gingivalis 線毛タイプ別感染実態の検討

巢式PCR按菌毛类型检测儿童口腔牙龈卟啉单胞菌感染的实际状况

• 发表时间: 2013
• 作者: Sasaki;M.;Kodama;Y.;Shimoyama;Y.;Kimura;S;下山 佑,木村美澄,佐々木実,根本優子,古玉芳豊,上戸幸美,田中光郎,木村重信
• 通讯作者: 下山 佑,木村美澄,佐々木実,根本優子,古玉芳豊,上戸幸美,田中光郎,木村重信

Maternal transmission of mutans and other oral streptococcal species

变形链球菌和其他口腔链球菌的母体传播

• 发表时间: 2011
• 作者: Otake-Asakawa;A.;Harada-Oikawa;R.;Ohara-Nemoto;Y.;Tanaka;M. and Kimura;S
• 通讯作者: S

The involvement of Streptococcus anginosus infection and AID expression in oral cancers.

口腔癌中咽峡炎链球菌感染和 AID 表达的参与。

• 发表时间: 2014
• 作者: M. Sasaki;K. Iwasaki;Y. Kodama;Y. Shimoyama;T. Ishikawa;Y. Sugiyama;S. Kimura
• 通讯作者: S. Kimura

Interface oral health science 2011

• DOI: 10.1007/978-4-431-54070-0
• 发表时间: 2012
• 作者: K. Sasaki;O. Suzuki;N. Takahashi;P. Stashenko;M. Cambridge