Basic research for chronotherapy focused on liver regeneration andliver steatosis by circadian clock

通过生物钟进行肝脏再生和肝脏脂肪变性的时间疗法基础研究

• 批准号: 23659398
• 负责人: TERAI Shuji
• 金额: $ 2.33万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659398/
• 关键词: NASH; 肝障害; サーカディアンリズム; 脂肪肝; 肝再生; サーカデイアンリズム

Medaka with HFD showed high NASH activity score (NAS), suggesting that circadian rhythm change is related to NASH progression. The light system is closely related with chronic inflammation by light stimulation. Collaboration with Oklahoma university, we found that NASH medaka developed diabetic nephropathy. These data showedmedaka fish model is useful to analyze the mechanism of NASH and nephropathyand to develop a new chronotherapy.

患有 HFD 的青鳉表现出较高的 NASH 活动评分 (NAS)，表明昼夜节律变化与 NASH 进展相关。光系统与光刺激引起的慢性炎症密切相关。我们与俄克拉荷马大学合作，发现NASH青鳉患上了糖尿病肾病。这些数据表明青鳉鱼模型有助于分析 NASH 和肾病的机制并开发新的时间疗法。

项目成果

Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy.

• DOI: 10.1016/j.bbrc.2013.01.053
• 发表时间: 2013-02-22
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Ichimura, Koichiro;Kawashima, Yusuke;Nakamura, Tomomi;Powell, Rebecca;Hidoh, Yuya;Terai, Shuji;Sakaida, Isao;Kodera, Yoshio;Tsuji, Takashi;Ma, Jian-Xing;Sakai, Tatsuo;Matsumoto, Hiroyuki;Obara, Tomoko
• 通讯作者: Obara, Tomoko

HHM(Maid) is a specific regulator to inhibit the generation of liver tumor and progression of liver fibrosis-From the studyof CCl4 induced Maid KO mice and DEN exposure HHM Tg medaka fish-

HHM(Maid)是抑制肝肿瘤生成和肝纤维化进展的特异性调节剂-来自CCl4诱导Maid KO小鼠和DEN暴露HHM Tg青鳉鱼的研究-

• 发表时间: 2011
• 作者: Shuji Terai;Naoki Yamamoto;Koichi Fujisawa;Tomoaki Murata;Isao Sakaida
• 通讯作者: Isao Sakaida

SMP30/Regucalcin is a useful marker for liver tumor

SMP30/Reguccalcin 是肝肿瘤的有用标记物

• 发表时间: 2011
• 作者: Koichi Fujisawa;Shuji Terai;Taro Takami;Naoki Yamamoto;Isao Sakaida
• 通讯作者: Isao Sakaida

メダカおよびマウスを用いた非アルコール性脂肪肝炎の病態研究および薬物スクリーニング

青鳉和小鼠非酒精性脂肪性肝炎的病理学研究及药物筛选

• 发表时间: 2013
• 作者: Sugimura K;Fukumoto Y;Satoh K;Nochioka K;Miura Y;Aoki T;Tatebe S;Miyamichi-Yamamoto S;Shimokawa H;寺井 崇二
• 通讯作者: 寺井 崇二

Ezetimibe reduces fatty acid quantity in liver and decreased inflammatory cell infiltration and improved NASH in medaka model.

• DOI: 10.1016/j.bbrc.2012.04.087
• 发表时间: 2012-05
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Toshiyuki Oishi;S. Terai;Shinya Kuwashiro;K. Fujisawa;Toshihiko Matsumoto;H. Nishina;I. Sakaida