analysis of cancer immune reaction by irradiation

放射线癌症免疫反应分析

• 批准号: 18K07740
• 负责人: Shun-Ichiro Kageyama
• 金额: $ 2.83万
• 依托单位: National Cancer Center Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K07740/
• 关键词: 放射線治療; 食道癌; STING; PD-L1; 免疫チェックポイント; Radiation; Esophageal Cancer; Type I interferon; 放射線; 免疫; RNA seq; がん免疫療法; がん免役; JAK-STAT

项目成果

Enhanced tumor response to radiotherapy after PD-1 blockade in metastatic gastric cancer

PD-1阻断后转移性胃癌肿瘤对放疗的反应增强

• DOI: 10.1007/s10120-020-01058-4
• 发表时间: 2020-03-16
• 期刊: Gastric Cancer
• 影响因子: 7.4
• 作者: Akinori Sasaki;Y. Nakamura;Y. Togashi;H. Kuno;H. Hojo;S. Kageyama;N. Nakamura;K. Takashima;T. Kadota;Y. Yoda;S. Mishima;K. Sawada;D. Kotani;A. Kawazoe;Y. Kuboki;H. Taniguchi;T. Kojima;T. Doi;T. Yoshino;T. Yano;Tatsushi Kobayashi;T. Akimoto;H. Nishikawa;K. Shitara
• 通讯作者: K. Shitara

TENERGY: multicenter phase II study of Atezolizumab monotherapy following definitive Chemoradiotherapy with 5-FU plus Cisplatin in patients with unresectable locally advanced esophageal squamous cell carcinoma.

TENERGY：对不可切除的局部晚期食管鳞状细胞癌患者进行 5-FU 加顺铂根治性放化疗后 Atezolizumab 单药治疗的多中心 II 期研究。

• 发表时间: 2020
• 作者: B;o H; Kotani D; Tsushima T; Hara H; Kadowaki S; Kato K; Chin K; Yamaguchi K; Kageyama SI; Hojo H; Nakamura M; Tachibana H; Wakabayashi M; Fukutani M; Togashi Y; Fuse N; Nishikawa H; Kojima T.
• 通讯作者: Kojima T.

Differences in failure patterns according to the EGFR mutation status after proton beam therapy for early stage non-small cell lung cancer.

质子束治疗早期非小细胞肺癌后，根据 EGFR 突变状态的失败模式存在差异。

• DOI: 10.1016/j.radonc.2020.04.056
• 发表时间: 2020-05-05
• 期刊: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
• 作者: M. Nakamura;S. Kageyama;H. Udagawa;Y. Zenke;K. Yoh;S. Niho;H. Hojo;A. Motegi;K. Kirita;S. Matsumoto;K. Goto;T. Akimoto
• 通讯作者: T. Akimoto

Identification of the mutation signature of the cancer genome caused by irradiation

辐射引起的癌症基因组突变特征的鉴定

• 发表时间: 2021
• 作者: Kageyama SI; Junyan D; Hojo H; Motegi A; Nakamura M; Tsuchihara K; Akimoto T.
• 通讯作者: Akimoto T.

Identification of the mutation signature of the cancer genome caused by irradiation

辐射引起的癌症基因组突变特征的鉴定

• 发表时间: 2021
• 作者: Kageyama SI; Junyan D; Hojo H; Motegi A; Nakamura M; Tsuchihara K; Akimoto T.
• 通讯作者: Akimoto T.