The Beta-3 adrenergic receptor has a possibility to improve the mortality with sepsis-induced cardiac dysfunction by regulating cardiac metabolism.

Beta-3 肾上腺素能受体有可能通过调节心脏代谢来改善脓毒症引起的心脏功能障碍的死亡率。

• 批准号: 18K16505
• 负责人: KAWAGUCHI SATOSHI
• 金额: $ 2.66万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K16505/
• 关键词: 敗血症; 敗血症性心機能障害; β3アドレナリン受容体; 心筋エネルギー代謝; iNOS; NO; ミトコンドリア機能; 脂肪酸代謝; リポポリサッカロイド; 敗血症性心筋症; 心筋代謝

项目成果

Endotoxin Induced Cardiac Metabolic Shift is Controlled Through the Regulation of Fatty Acid Oxidation by a Beta-3 Adrenergic Receptor

通过 Beta-3 肾上腺素受体调节脂肪酸氧化来控制内毒素诱导的心脏代谢转变

• 发表时间: 2018
• 作者: Satoshi Kawaguchi;Motoi Okada;Satoshi Fujita;Naoyuki Hasebe
• 通讯作者: Naoyuki Hasebe

Cardiac Metabolism was Improved by Regulation of Nitric Oxide Synthase Through The Beta-3 Adrenergic Receptor in Endotoxin-induced Failing Heart

在内毒素引起的心力衰竭中，通过 Beta-3 肾上腺素能受体调节一氧化氮合酶，改善心脏代谢

• 发表时间: 2019
• 作者: Satoshi Kawaguchi;Motoi Okada;Satoshi Fujita;Naoyuki Hasebe
• 通讯作者: Naoyuki Hasebe

Beta-3 adrenergic receptor blockade reduces mortality with septic cardiomyopathy by saving cardiac energy metabolism and mitochondrial function

Beta-3 肾上腺素能受体阻断可通过节省心脏能量代谢和线粒体功能来降低脓毒症心肌病的死亡率

• 发表时间: 2018
• 作者: Satoshi Kawaguchi;Motoi Okada;Satoshi Fujita;Naoyuki Hasebe
• 通讯作者: Naoyuki Hasebe

Blockade of beta-3 adrenergic receptor ameliorates septic cardiomyopathy through the improvement of cardiac fatty acid oxidation

阻断 β3 肾上腺素能受体可通过改善心脏脂肪酸氧化来改善脓毒症心肌病

• 发表时间: 2018
• 作者: Satoshi Kawaguchi;Motoi Okada;Naoyuki Hasebe;Satoshi Fujita
• 通讯作者: Satoshi Fujita

The Blockade of Beta-3 Adrenergic Receptor Improves Prognosis of the Sepsis-Related Heart Failure by Stabilization of the Heart Metabolism

阻断 Beta-3 肾上腺素能受体通过稳定心脏代谢改善脓毒症相关心力衰竭的预后

• 发表时间: 2018
• 作者: Satoshi Kawaguchi;Motoi Okada;Satoshi Fujita;Naoyuki Hasebe
• 通讯作者: Naoyuki Hasebe