Development of new methods for the analysis of cytotoxicity by food additives

食品添加剂细胞毒性分析新方法的开发

• 批准号: 18K14408
• 负责人: Kamemura Norio
• 金额: $ 2.5万
• 依托单位: Tokushima Bunri University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K14408/
• 关键词: 食品添加物; 細胞毒性試験; 細胞内カルシウム; 細胞内亜鉛; Azoxystrobin; ポストハーベスト; 亜鉛

项目成果

Thiopental Elevates Steady-State Levels of Intracellular Ca2+ and Zn2+ in Rat Thymic Lymphocytes

硫喷妥钠提高大鼠胸腺淋巴细胞细胞内 Ca2 和 Zn2 的稳态水平

• DOI: 10.25026/jtpc.v5i2.259
• 发表时间: 2020
• 期刊: Journal of Tropical Pharmacy and Chemistry
• 作者: Kamemura Norio;Oyama Keisuke;Ueno Shinya;Mizobuchi Mizuki;Ishidoh Kazumi;Kanematsu Naoki
• 通讯作者: Kanematsu Naoki

Biphenyl-induced cytotoxicity is mediated by an increase in intracellular Zn2+

联苯诱导的细胞毒性是通过细胞内 Zn2 的增加介导的

• DOI: 10.1080/01480545.2018.1499771
• 发表时间: 2018
• 期刊: Drug and Chemical Toxicology
• 影响因子: 2.6
• 作者: Ae Masamichi;Imura Naohiro;Inubushi Tomoko;Abe Shin;Yusuke Bekki;Sugimoto Mayumi;Kamemura Norio
• 通讯作者: Kamemura Norio

Change in membrane potential induced by streptolysin O, a pore‐forming toxin: flow cytometric analysis using a voltage‐sensitive fluorescent probe and rat thymic lymphocytes

链球菌溶血素 O（一种成孔毒素）引起的膜电位变化：使用电压敏感荧光探针和大鼠胸腺淋巴细胞进行流式细胞术分析

• DOI: 10.1111/1348-0421.12748
• 发表时间: 2019
• 期刊: Microbiology and Immunology
• 影响因子: 2.6
• 作者: Miho Kobayashi;Madoka Nishimura;Mina Kawamura;Norio Kamemura;Hideaki Nagamune;Atsushi Tabata
• 通讯作者: Atsushi Tabata

Azoxystrobin at sub-cytotoxic concentrations disrupts intracellular zinc homeostasis: A flow cytometric analysis with rat thymic lymphocytes and fluorescent probes

• DOI: 10.2131/fts.7.1
• 发表时间: 2020
• 期刊: Fundamental Toxicological Sciences
• 作者: Mai Shoji;Masaki Asada;Akihiko Matsumoto;Haruki Nishino;Ao Yi Xiang;Mizuki Mizobuchi;Naoki Kanematsu;Hajime Miura;Norio Kamemura

Butylated hydroxytoluene, a food additive, modulates membrane potential and increases the susceptibility of rat thymocytes to oxidative stress

食品添加剂丁基羟基甲苯可调节膜电位并增加大鼠胸腺细胞对氧化应激的敏感性

• DOI: 10.1016/j.comtox.2018.04.001
• 发表时间: 2018
• 期刊: Computational Toxicology
• 作者: Ohue-Kitano R;Taira S;Watanabe K;Masujima Y;Kuboshima T;Miyamoto J;Nishitani Y;Kawakami H;Kuwahara H;Kimura I.;Kamemura Norio
• 通讯作者: Kamemura Norio