A proposed novel method for screening caloric restriction mimetics and its application

一种筛选热量限制模拟物的新方法及其应用

• 批准号: 19K11707
• 负责人: Nakajima Mitsunari
• 金额: $ 2.75万
• 依托单位: Matsuyama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K11707/
• 关键词: カロリー制限模倣物; 健康寿命延伸物質; SIRT1; ドラッグリポジショニング; カロリー制限模放物; 健康寿命; 長寿命遺伝子

项目成果

Cynandione A causes a dynamic change in SIRT1 nuclear trafficking via PKA signaling and beige adipocyte differentiation in 3T3-L1 cells

Cynandione A 通过 PKA 信号传导和 3T3-L1 细胞中的米色脂肪细胞分化引起 SIRT1 核运输的动态变化

• DOI: 10.1016/j.ejphar.2021.174382
• 发表时间: 2021
• 影响因子: 5
• 作者: Atsushi Sawamoto; Asami Kanazaki; Masayuki Nakanishi; Yoshiaki Amakura; Morio Yoshimura; Nahoko Uchiyama; Takashi Hakamatsuka; Satoshi Okuyama; Mitsunari Nakajima
• 通讯作者: Mitsunari Nakajima

Cynandione A induces adipogenesis and beige adipocyte-related phenotype in 3T3-L1 cells

Cynandione A 诱导 3T3-L1 细胞脂肪生成和米色脂肪细胞相关表型

• DOI: 10.1016/j.phytol.2020.07.011
• 发表时间: 2020-10-01
• 期刊: Phytochemistry Letters
• 影响因子: 1.7
• 作者: A. Sawamoto;Asami Kanazaki;Y. Amakura;Morio Yoshimura;N. Masumoto;N. Uchiyama;T. Hakamatsuka;S. Okuyama;Y. Furukawa;M. Nakajima
• 通讯作者: M. Nakajima

T-cell activation-inhibitory assay: a proposed novel method for screening caloric restriction mimetics

T 细胞激活抑制测定：一种拟议的筛选热量限制模拟物的新方法

• DOI: 10.2220/biomedres.40.235
• 发表时间: 2019
• 作者: Iura S; Ojima Y; Amakura Y; Yoshimura M; Sawamoto A; Okuyama S; Furukawa Y; Nakajima M.
• 通讯作者: Nakajima M.

Heptamethoxyflavone inhibits adipogenesis via enhancing PKA signaling.

七甲氧基黄酮通过增强 PKA 信号传导抑制脂肪生成。

• DOI: 10.1016/j.ejphar.2019.172758
• 发表时间: 2019-12-15
• 期刊: European journal of pharmacology
• 作者: A. Sawamoto;M. Nakanishi;S. Okuyama;Y. Furukawa;M. Nakajima
• 通讯作者: M. Nakajima

Identification of the characteristic components in walnut and anti-inflammatory effect of glansreginin A as an indicator for quality evaluation.

核桃中特征成分的鉴定及以君兰素A的抗炎作用作为质量评价指标

• DOI: 10.1080/09168451.2019.1670046
• 发表时间: 2020
• 作者: Haramiishi R; Okuyama S; Yoshimura M; Nakajima M; Furukawa Y; Ito H; Amakura Y.
• 通讯作者: Amakura Y.