Development of a novel antibody therapy for Alzheimer's disease using anti-Abeta oligomeric minimal fragment antibodies

使用抗 Abeta 寡聚最小片段抗体开发针对阿尔茨海默病的新型抗体疗法

• 批准号: 19K07998
• 负责人: Yabuuchi Kenichi
• 金额: $ 2.83万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K07998/
• 关键词: Aβオリゴマー; アルツハイマー型認知症; Aβオリゴマー抗体; CDRペプチド; マイクロダイアリシス; Aβオリゴマー特異的抗体

项目成果

Association of Modifiable Lifestyle Factors With Cortical Amyloid Burden and Cerebral Glucose Metabolism in Older Adults With Mild Cognitive Impairment.

可改变的生活方式因素与轻度认知障碍老年人皮质淀粉样蛋白负担和脑葡萄糖代谢的关系。

• DOI: 10.1001/jamanetworkopen.2020.5719
• 发表时间: 2020
• 作者: Kimura N; Aso Y; Yabuuchi K; Ishibashi M; Hori D; Sasaki Y; Nakamichi A; Uesugi S; Jikumaru M; Sumi K; Eguchi A; Obara H; Kakuma T; Matsubara E.
• 通讯作者: Matsubara E.

Modifiable Lifestyle Factors and Cognitive Function in Older People: A Cross-Sectional Observational Study.

老年人可改变的生活方式因素和认知功能：横断面观察研究。

• DOI: 10.3389/fneur.2019.00401
• 发表时间: 2019
• 作者: Kimura N; Aso Y; Yabuuchi K; Ishibashi M; Hori D; Sasaki Y; Nakamichi A; Uesugi S; Fujioka H; Iwao S; Jikumaru M; Katayama T; Sumi K; Eguchi A; Nonaka S; Kakumu M; Matsubara E.
• 通讯作者: Matsubara E.

Association of Modifiable Lifestyle Factors With Cortical Amyloid Burden and Cerebral Glucose Metabolism in Older Adults With Mild Cognitive Impairment.

可改变的生活方式因素与轻度认知障碍老年人皮质淀粉样蛋白负担和脑葡萄糖代谢的关系。

• DOI: 10.1001/jamanetworkopen.2020.5719
• 发表时间: 2020
• 作者: Kimura N; Aso Y; Yabuuchi K; Ishibashi M; Hori D; Sasaki Y; Nakamichi A; Uesugi S; Jikumaru M; Sumi K; Eguchi A; Obara H; Kakuma T; Matsubara E.
• 通讯作者: Matsubara E.

Association between objectively measured walking steps and sleep in community-dwelling older adults: A prospective cohort study.

客观测量的社区老年人步行步数与睡眠之间的关联：一项前瞻性队列研究。

• DOI: 10.1371/journal.pone.0243910
• 发表时间: 2020
• 作者: Kimura N; Aso Y; Yabuuchi K; Matsubara E.
• 通讯作者: Matsubara E.

Relationship Between the Japanese Version of the Montreal Cognitive Assessment and PET Imaging in Subjects with Mild Cognitive Impairment.

日本版蒙特利尔认知评估与轻度认知障碍受试者 PET 成像之间的关系。

• DOI: 10.2174/1567205016666190805155230
• 发表时间: 2019
• 作者: Eguchi A; Kimura N; Aso Y; Yabuuchi K; Ishibashi M; Hori D; Sasaki Y; Nakamichi A; Uesugi S; Jikumaru M; Sumi K; Shimomura T; Matsubara E.
• 通讯作者: Matsubara E.