Fabrication of bioactive zirconia implant

生物活性氧化锆植入物的制造

• 批准号: 19K10250
• 负责人: バラネザハド 有礼左
• 金额: $ 2.75万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K10250/
• 关键词: implant; zirconia; vioactivity; Implant; Zirconia; Bioactivity; インプラント; ジルコニア; 生体活性; 生体材料; 骨形成

Ceramic 45S5 BG (45%SiO2, 24.5%Na2O, 24.5%CaO, and 6%P2O5 by weight) have gained researchers attention as a functional biomaterial due to its bioactive surface and osseointegration ability. It has been approved that BG 45S5 can heal and repair bone damages. Therefore, The sol-gel technique preparation protocol followed to prepare 45S5 BG, by mixing the tetraethylorthosilicate (TEOS, Wako, Tokyo, Japan), nitric acid, triethylphosphate (TEP, Wako, Japan), calcium nitrate tetrahydrate (Wako), sodium nitrate (Wako). The zirconia substrates coated by one-time vacuum sol-dipping method under 0.1 bar pressure dipped for 60 s and dried at 60°C for 1 hour followed by sintering at 1200°C for 1 hour to melt the BG on the surface in a programmable furnace with a heating rate of 10°C/min. The characterizations such as morphology, adhesion test and roughness investigated after BG coating. The SEM images confirmed that 900°C is not enough to melt and cover entire surface therefore 1200°C was applied. Also the Fractography result showed that the thickness of the coating layer is controllable between 5 um to 45 um. The XRD result mentioned the non-crystallin and crystalline BG phase structures.

陶瓷45S5 BG（按重量计含有45%SiO2、24.5%Na2O、24.5%CaO和6%P2O5）因其生物活性表面和骨整合能力而作为一种功能性生物材料受到研究人员的关注。BG 45S5已被证实可以愈合和愈合。因此，遵循溶胶-凝胶技术制备方案来制备 45S5 BG，通过混合原硅酸四乙酯（TEOS，和光，日本东京）、硝酸、磷酸三乙酯（TEP，和光，日本）、四水合硝酸钙（和光）、硝酸钠（和光）采用一次性真空溶胶浸渍法涂覆氧化锆基材。 0.1巴压力下浸渍60秒并在60°C下干燥1小时，然后在100℃下烧结在可编程熔炉中以 10°C/min 的加热速率在 1200°C 下熔化表面上的 BG。 BG 涂层后研究的形貌、附着力测试和粗糙度等特性经 SEM 图像证实。 C不足以熔化并覆盖整个表面，因此采用1200℃，并且断口分析结果表明涂层的厚度可控制在5μm至45μm之间。嗯，X射线衍射结果提到了非晶态和晶态BG相结构。