Targeting cancer stem cells and spatial niches in kidney cancer: Unravelling intratumoral heterogeneity

靶向肾癌中的癌症干细胞和空间生态位：揭示肿瘤内异质性

• 批准号: 19H03792
• 负责人: TANAKA NOBUYUKI
• 金额: $ 11.23万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19H03792/
• 关键词: 腎細胞癌; 分子標的治療; 免疫治療; イメージング; シークエンス; 免疫療法; RNAシークエンス; ライトシート顕微鏡; 腫瘍内不均一性; 免疫微小環境; 膨張顕微鏡法; 循環腫瘍細胞; がん組織不均一性

项目成果

Multiplexed single-cell pathology reveals the association of CD8 T-cell heterogeneity with prognostic outcomes in renal cell carcinoma

多重单细胞病理学揭示 CD8 T 细胞异质性与肾细胞癌预后结果的关联

• DOI: 10.1007/s00262-021-03006-2
• 发表时间: 2021-07-14
• 期刊: Cancer Immunology, Immunotherapy
• 作者: T. Murakami;N. Tanaka;Kimiharu Takamatsu;Kyohei Hakozaki;K. Fukumoto;Tsukasa Masuda;S. Mikami;T. Shinojima;K. Kakimi;T. Tsunoda;K. Sawada;Takeshi Imamura;R. Mizuno;M. Oya
• 通讯作者: M. Oya

Unique characteristics of tertiary lymphoid structures in kidney clear cell carcinoma: prognostic outcome and comparison with bladder cancer

肾透明细胞癌三级淋巴结构的独特特征：预后结果以及与膀胱癌的比较

• DOI: 10.1136/jitc-2021-003883
• 发表时间: 2022
• 影响因子: 10.9
• 作者: Masuda Tsukasa;Tanaka Nobuyuki;Takamatsu Kimiharu;Hakozaki Kyohei;Takahashi Ryohei;Anno Tadatsugu;Kufukihara Ryohei;Shojo Kazunori;Mikami Shuji;Shinojima Toshiaki;Kakimi Kazuhiro;Tsunoda Tatsuhiko;Aimono Eriko;Nishihara Hiroshi;Mizuno Ryuichi;Oya Mototsug
• 通讯作者: Oya Mototsug

TNFAIP2 expression induces epithelial-to-mesenchymal transition and confers platinum resistance in urothelial cancer cells.

TNFAIP2 表达诱导上皮间质转化并赋予尿路上皮癌细胞铂类耐药性。

• DOI: 10.1038/s41374-019-0285-y
• 发表时间: 2019
• 影响因子: 5
• 作者: Niwa N; Tanaka N; Hongo H; Miyazaki Y; Takamatsu K; Mizuno R; Kikuchi E; Mikami S; Kosaka T; Oya M.
• 通讯作者: Oya M.

Multiplexed single-cell pathology reveals the association of CD8 T-cell heterogeneity with prognostic outcomes in renal cell carcinoma

多重单细胞病理学揭示 CD8 T 细胞异质性与肾细胞癌预后结果的关联

• DOI: 10.1007/s00262-021-03006-2
• 发表时间: 2021
• 作者: Murakami Tetsushi;Tanaka Nobuyuki;Takamatsu Kimiharu;Hakozaki Kyohei;Fukumoto Keishiro;Masuda Tsukasa;Mikami Shuji;Shinojima Toshiaki;Kakimi Kazuhiro;Tsunoda Tatsuhiko;Sawada Kazuaki;Imamura Takeshi;Mizuno Ryuichi;Oya Mototsugu
• 通讯作者: Oya Mototsugu

Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies

用于分析完整肿瘤活检中 RNA 和蛋白质表达的三维单细胞成像

• DOI: 10.1038/s41551-020-0576-z
• 发表时间: 2020
• 影响因子: 28.1
• 作者: Tanaka Nobuyuki;Kanatani Shigeaki;Kaczynska Dagmara;Fukumoto Keishiro;Louhivuori Lauri;Mizutani Tomohiro;Kopper Oded;Kronqvist Pauliina;Robertson Stephanie;Lindh Claes;Kis Lor;Pronk Robin;Niwa Naoya;Matsumoto Kazuhiro;Oya Mototsugu;... Uhlen Per
• 通讯作者: ... Uhlen Per