Development of a gigaporechromatographic resins that enables rapid and large-scale separation of biopharmaceuticals

开发能够快速大规模分离生物制药的千兆孔色谱树脂

• 批准号: 20K05228
• 负责人: Kumada Yoichi
• 金额: $ 2.75万
• 依托单位: Kyoto Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K05228/
• 关键词: chromatography; human antibodies; anion-exchange; giga pore; antibody; protein therapeutics; anion exchanger; dynamic binding capacity; 貫通孔粒子; クロマトグラフィ分離; タンパク質; 高速分離; affinity chromatography; Giga pore; scFv; BNPs; mass transfer

项目成果

Strategies for selection and identification of rabbit single-chain Fv antibodies as ligand in affinity chromatographyYoichi Kumada, Haingomaholy Michelle Rakotondravao, Yuya Hasegawa, Yuki Iwashita, Hiromichi Okura, Seiichi Uchimura, Jun-ichi Horiuchi

选择和鉴定兔单链 Fv 抗体作为亲和层析配体的策略Yoichi Kumada, Haingomaholy Michelle Rakotondravao, Yuya Hasekawa, Yuki Iwashita, Hiromichi Okura, Seiichi Uchimura, Jun-ichi Horiuchi

• DOI: 10.1016/j.jbiosc.2022.06.002
• 发表时间: 2022
• 影响因子: 2.8
• 作者: Yoichi Kumada; Haingomaholy Michelle Rakotondravao; Yuya Hasegawa; Yuki Iwashita; Hiromichi Okura; Seiichi Uchimura; Jun
• 通讯作者: Jun

Control of Accessible Surface Areas and Height Equivalent to a Theoretical Plate using Grafted Dextran during Anion-Exchange Chromatography of Therapeutic Proteins

在治疗性蛋白质的阴离子交换层析过程中使用接枝葡聚糖控制可及表面积和相当于理论板的高度

• DOI: 10.1252/jcej.22we035
• 发表时间: 2022-08-20
• 期刊: JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
• 影响因子: 0.8
• 作者: Haingomaholy Michelle Rakotondravao;Ryosuke Takahashi;T. Takai;Yumiko Sakoda;J. Horiuchi;Y. Kumada
• 通讯作者: Y. Kumada

Control of Accessible Surface Areas and Height Equivalent to a Theoretical Plate using Grafted Dextran during Anion-Exchange Chromatography of Therapeutic Proteins

在治疗性蛋白质的阴离子交换层析过程中使用接枝葡聚糖控制可及表面积和相当于理论板的高度

• DOI: 10.1252/jcej.22we035
• 发表时间: 2022
• 影响因子: 0.8
• 作者: Haingomaholy Michelle Rakotondravao; Ryosuke Takahashi; Takatomo Takai; Yumiko Sakoda; Jun
• 通讯作者: Jun

Strategies for selection and identification of rabbit single-chain Fv antibodies as ligand in affinity chromatographyYoichi Kumada, Haingomaholy Michelle Rakotondravao, Yuya Hasegawa, Yuki Iwashita, Hiromichi Okura, Seiichi Uchimura, Jun-ichi Horiuchi

选择和鉴定兔单链 Fv 抗体作为亲和层析配体的策略Yoichi Kumada, Haingomaholy Michelle Rakotondravao, Yuya Hasekawa, Yuki Iwashita, Hiromichi Okura, Seiichi Uchimura, Jun-ichi Horiuchi

• DOI: 10.1016/j.jbiosc.2022.06.002
• 发表时间: 2022
• 影响因子: 2.8
• 作者: Yoichi Kumada; Haingomaholy Michelle Rakotondravao; Yuya Hasegawa; Yuki Iwashita; Hiromichi Okura; Seiichi Uchimura; Jun
• 通讯作者: Jun