Externally Triggered Nanomachine for Breast Cancer Theranostics

用于乳腺癌治疗的外部触发纳米机器

• 批准号: 20K05260
• 负责人: ルカノフ アレクサンダー
• 金额: $ 2.75万
• 依托单位: Gunma National College of Technology (2021-2022)Saitama University (2020)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K05260/
• 关键词: theranostics nanozyme; normoxia condition; B16-F10 melanoma; ATPase activity; breast cancer; noninvasive chemotherapy; Theranostic nanomachine; artificial nanozyme; carbon nanodots; breast cancer cells; Nanozyme; Carbon nanodots; Photosensitiz

A photo-oxidative nanozyme for cancer theranostics was demonstrated at normoxic conditions on breast cancer B16-F10 mouse melanoma with high metastatic potential. The experimental data revealed that the metastatic migration might be controlled by nanozyme and applied near-infrared energy dosage. The biocompatibility of the nanozyme was proved on ATPase activity of intact mitochondria and sub-mitochondrial particles, on diamine oxidase activity of liver and kidney fractions in dark mode, as well as on non-illuminated adenocarcinoma human alveolar basal epithelial cells (A549) and human liver cancer cells (HepG2). The effective therapeutic amount (~50 mg/l) was found to be 10-fold lower than the threshold dose (> 500 mg/l) and it did not influenced the signal pathways of the healthy cells.

在常氧条件下，在具有高转移潜力的乳腺癌 B16-F10 小鼠黑色素瘤中证明了一种用于癌症治疗诊断的光氧化纳米酶。实验数据表明，转移性迁移可能是通过纳米酶和施加近红外能量剂量来控制的。纳米酶的生物相容性在完整线粒体和亚线粒体颗粒的 ATP 酶活性、暗模式下肝脏和肾脏部分的二胺氧化酶活性以及非照明腺癌人肺泡基底上皮细胞 (A549) 和人的二胺氧化酶活性上得到了证明。肝癌细胞（HepG2）。研究发现，有效治疗量（~50 mg/l）比阈值剂量（> 500 mg/l）低10倍，并且不会影响健康细胞的信号通路。

项目成果

Biotechnological recycling and recovery of metals from secondary raw materials through biogenic synthesis of nanoparticles

通过纳米粒子的生物合成从二次原料中生物技术回收和回收金属

• 发表时间: 2021
• 期刊: Sustainable Extraction and Processing of Raw Materials Journal
• 作者: Svetlin Toshev;Alexandre Loukanov;Saim Emin;Seiichiro Nakabayashi
• 通讯作者: Seiichiro Nakabayashi

Metabolic labeling of Escherichia coli genomic DNA with erythrosine-11-dUTP for functional imaging via correlative microscopy

使用 erythrosine-11-dUTP 代谢标记大肠杆菌基因组 DNA，通过相关显微镜进行功能成像

• DOI: 10.1002/jemt.23487
• 发表时间: 2020
• 期刊: Microscopy Research and Technique
• 影响因子: 2.5
• 作者: Loukanov Alexandre;Nikolova Svetla;Filipov Chavdar;Nakabayashi Seiichiro
• 通讯作者: Nakabayashi Seiichiro

Light-triggered nanomachine for cancer theranostics

用于癌症治疗诊断的光触发纳米机器

• 发表时间: 2020
• 作者: Hiroshi Matsui;Kakeru Fukuda;Saki Takano,Yuka Ikemoto;Takahiko Sasaki;Yasumitsu Matsuo;Alexandre Loukanov
• 通讯作者: Alexandre Loukanov

Semi‐industrial remediation of effluents polluted by the artisanal activities through bipolar electrocoagulation with aluminum sacrificial electrodes

通过铝牺牲电极双极电凝对手工活动污染的废水进行半工业化修复

• DOI: 10.1111/wej.12581
• 发表时间: 2020
• 期刊: Water and Environment Journal
• 影响因子: 2
• 作者: El Allaoui Nouha;Omor Anass;Elmadani Fatima Zahra;Bouayad Kenza;Nakabayashi Seiichiro;Loukanov Alexandre
• 通讯作者: Loukanov Alexandre

Light-triggered Janus nanomotor for targeting and photothermal lysis of pathogenic bacteria

• DOI: 10.1002/jemt.23657
• 发表时间: 2020-11-27
• 期刊: MICROSCOPY RESEARCH AND TECHNIQUE
• 影响因子: 2.5
• 作者: Loukanov, Alexandre