Mechanism of the Plasticity of Innate Immunity during Metabolic Re-compensation in Liver Cirrhosis

肝硬化代谢再代偿过程中先天免疫的可塑性机制

• 批准号: 19K17502
• 负责人: CHU Po-sung
• 金额: $ 2.75万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K17502/
• 关键词: 自然免疫; fibrolysis; 腸内細菌; 胆汁酸; acute-on-chronic肝不全; 肝線維化; マクロファージ; 胆汁酸代謝; liver fibrosis; innate immunity

项目成果

Toll-like receptor 4 signaling in bone marrow-derived macrophages promotes resolution of carbon tetrachloride-induced murine liver fibrosis

骨髓源性巨噬细胞中的 Toll 样受体 4 信号传导促进四氯化碳诱导的小鼠肝纤维化的消退

• 发表时间: 2020
• 作者: Takimoto Y; Chu P
• 通讯作者: Chu P

Clinical implications with tolvaptan on monitored bioimpedance-defined fluid status in patients with cirrhotic ascites: an observational study

托伐普坦对肝硬化腹水患者生物阻抗定义液体状态监测的临床意义：一项观察性研究

• DOI: 10.1186/s12876-020-01205-2
• 发表时间: 2020
• 影响因子: 2.4
• 作者: Shiba Shunsuke;Chu Po;Nakamoto Nobuhiro;Yamataka Karin;Taniki Nobuhito;Ojiro Keisuke;Yamaguchi Akihiro;Morikawa Rei;Yoshida Aya;Ikura Akihiko;Ebinuma Hirotoshi;Saito Hidetsugu;Kanai Takanori
• 通讯作者: Kanai Takanori

Clinical features and natural history of acute-on-chronic liver failure precipitated by any indeterminate factor: single-center observational study

任何不确定因素引发的慢加急性肝衰竭的临床特征和自然史：单中心观察性研究

• 发表时间: 2020
• 作者: Hoshi H; Chu P
• 通讯作者: Chu P

Toll-like receptor 4 signaling in bone marrow-derived macrophages promotes resolution of carbon tetrachloride-induced murine liver fibrosis

骨髓源性巨噬细胞中的 Toll 样受体 4 信号传导促进四氯化碳诱导的小鼠肝纤维化的解决

• 发表时间: 2020
• 作者: Takimoto Y; Chu P
• 通讯作者: Chu P

Clinical features and natural history of acute-on-chronic liver failure precipitated by any indeterminate factor: single-center observational study

任何不确定因素引发的慢加急性肝衰竭的临床特征和自然史：单中心观察性研究

• 发表时间: 2020
• 作者: Hoshi H; Chu P
• 通讯作者: Chu P