Development of a method to examine the relationship between phenotype and individual differences in gene expression without the need for gene expression data from a large number of people.

开发一种方法来检查表型与基因表达个体差异之间的关系，而不需要大量人群的基因表达数据。

• 批准号: 19K20394
• 负责人: Ozaki Haruka
• 金额: $ 2.58万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K20394/
• 关键词: 機械学習; 遺伝子発現; 深層学習; 表現型予測; ゲノム配列; シングルセルRNA-seq

项目成果

MOCCS profile analysis clarifies the cell type dependency of transcription factor-binding sequences and cis-regulatory SNPs in humans

MOCCS 谱分析阐明了人类转录因子结合序列和顺式调节 SNP 的细胞类型依赖性

• 发表时间: 2022
• 作者: Saeko Tahara;Takaho Tsuchiya;Hirotaka Matsumoto;Haruka Ozaki
• 通讯作者: Haruka Ozaki

Stability of RNA sequences derived from the coronavirus genome in human cells

• DOI: 10.1016/j.bbrc.2020.05.008
• 发表时间: 2020-07-05
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Wakida, Hiroyasu;Kawata, Kentaro;Akimitsu, Nobuyoshi
• 通讯作者: Akimitsu, Nobuyoshi

Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity

• DOI: 10.1126/scisignal.aaz1236
• 发表时间: 2020-12-01
• 期刊: SCIENCE SIGNALING
• 影响因子: 7.3
• 作者: Kokaji, Toshiya;Hatano, Atsushi;Kuroda, Shinya
• 通讯作者: Kuroda, Shinya

MOCCS-DB: ヒト転写因子認識配列の多様性データベース

MOCCS-DB：人类转录因子识别序列多样性数据库

• 发表时间: 2022
• 作者: Yuki Katsumata;Akira Taniguchi;Lotfi El Hafi;Yoshinobu Hagiwara;Tadahiro Taniguchi;田原 沙絵子,土屋 貴穂,松澤 亮輔,尾崎 遼
• 通讯作者: 田原 沙絵子,土屋 貴穂,松澤 亮輔,尾崎 遼

In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states.

• DOI: 10.1038/s41598-022-17964-9
• 发表时间: 2022-08-12
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Kokaji, Toshiya;Eto, Miki;Hatano, Atsushi;Yugi, Katsuyuki;Morita, Keigo;Ohno, Satoshi;Fujii, Masashi;Hironaka, Ken-ichi;Ito, Yuki;Egami, Riku;Uematsu, Saori;Terakawa, Akira;Pan, Yifei;Maehara, Hideki;Li, Dongzi;Bai, Yunfan;Tsuchiya, Takaho;Ozaki, Haruka;Inoue, Hiroshi;Kubota, Hiroyuki;Suzuki, Yutaka;Hirayama, Akiyoshi;Soga, Tomoyoshi;Kuroda, Shinya
• 通讯作者: Kuroda, Shinya