Development of a new sense oligonucleotide drug targeting inducible nitric oxide synthase for sepsis model rats

脓毒症模型大鼠靶向诱导型一氧化氮合酶的新型寡核苷酸药物的研制

• 批准号: 19K18370
• 负责人: NAKATAKE Richi
• 金额: $ 2.66万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K18370/
• 关键词: 敗血症; 核酸医薬; センスオリゴヌクレオチド; 誘導型一酸化窒素合成酵素; 肝細胞; センスオリゴ ヌクレオチド; センスオリゴ; 非コードRNA; エンドトキシン血症; 肝不全

项目成果

Protective effect of the proton pump inhibitor lansoprazole in lethal acute liver failure induced by D-galactosamine and lipopolysaccharide in rats.

质子泵抑制剂兰索拉唑对 D-半乳糖胺和脂多糖诱导的致死性急性肝衰竭大鼠的保护作用。

• 发表时间: 2020
• 作者: Richi Nakatake;Hidehiko Hishikawa ;Masaya Kotsuka ;Katsuhiko Yoshizawa;Mikio Nishizawa;Tadayoshi Okumura ;Rene H. Tolba and Mitsugu Sekimoto
• 通讯作者: Rene H. Tolba and Mitsugu Sekimoto

The protective effects of a sense oligonucleotide drug targeting inducible nitric oxide synthase for a rat model of acute liver injury.

靶向诱导型一氧化氮合酶的正义寡核苷酸药物对急性肝损伤大鼠模型的保护作用。

• 发表时间: 2020
• 作者: Richi Nakatake;Tetsuya Okuyama;Masaki Kaibori;Tadayoshi Okumura;Mitsugu Sekimoto;Rene H. Tolba and Mikio Nishizawa.
• 通讯作者: Rene H. Tolba and Mikio Nishizawa.

Active Hexose Correlated Compound Has Protective Effects in Ischemia?Reperfusion Injury of the Rat Small Intestine

活性己糖相关化合物对大鼠小肠缺血再灌注损伤的保护作用

• DOI: 10.1016/j.jss.2019.05.047
• 发表时间: 2019
• 期刊: Journal of Surgical Research
• 影响因子: 2.2
• 作者: Ueyama Yosuke;Tokuhara Katsuji;Miki Hirokazu;Nakatake Richi;Sakaguchi Tatsuma;Nishizawa Mikio;Kaibori Masaki;Okumura Tadayoshi
• 通讯作者: Okumura Tadayoshi

Essential amino acid tryptophan has a liver-protective effect through the suppression of inducible nitric oxide synthase in primary cultured rat hepatocytes.

必需氨基酸色氨酸通过抑制原代培养的大鼠肝细胞中的诱导型一氧化氮合酶而具有肝脏保护作用。

• 发表时间: 2019
• 作者: Richi Nakatake;Takumi Tsuda;Hirokazu Miki;Tatsuma Sakaguchi,Masaya Kotsuka;Masaki Kaibori;Tadayoshi Okumura;Mikio Nishizawa;and Mitsugu Sekimoto.
• 通讯作者: and Mitsugu Sekimoto.

Cinnamomi Cortex and Scutellariae Radix in the Japanese herbal medicine Kampo saireito inhibit expression of iNOS through different mechanisms in hepatocytes

日本草药汉方药材中的肉桂和黄芩通过不同机制抑制肝细胞中 iNOS 的表达

• DOI: 10.1002/tkm2.1241
• 发表时间: 2020
• 期刊: Traditional & Kampo Medicine
• 作者: Matsushima Hideyuki;Hishikawa Hidehiko;Miki Hirokazu;Hatta Masahiko;Nakatake Richi;Okumura Tadayoshi;Nishizawa Mikio;Kaibori Masaki;Sekimoto Mitsugu
• 通讯作者: Sekimoto Mitsugu