Development of new antihypertensive drug by comprehensive analysis of WNK signal

综合分析WNK信号开发降压新药

• 批准号: 20K17244
• 负责人: ISOBE KIYOSHI
• 金额: $ 2.66万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K17244/
• 关键词: WNK; アクアポリン２; ミオシン軽鎖キナーゼ; リン酸化プロテオミクス; 高血圧; WNKキナーゼ; 塩分感受性高血圧; WNK4; メタボリックシンドローム; WNK1; Proteomics

项目成果

Structural Development of Salicylanilide‐Based SPAK Inhibitors as Candidate Antihypertensive Agents

• DOI: 10.1002/cmdc.202100273
• 发表时间: 2021-06
• 期刊: ChemMedChem
• 影响因子: 3.4
• 作者: S. Fujii;Eriko Kikuchi;Honoka Suzuyama;Y. Watanabe;Mari Ishigami‐Yuasa;H. Masuno;Takayasu Mori;Kiyoshi Isobe;S. Uchida;H. Kagechika

Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease

• DOI: 10.1016/j.kint.2019.11.021
• 发表时间: 2020-04-01
• 期刊: KIDNEY INTERNATIONAL
• 影响因子: 19.6
• 作者: Furusho, Taisuke;Sohara, Eisei;Uchida, Shinichi
• 通讯作者: Uchida, Shinichi

Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling

• DOI: 10.1016/j.bmcl.2020.127408
• 发表时间: 2020-09-01
• 期刊: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
• 影响因子: 2.7
• 作者: Fujii, Shinya;Kikuchi, Eriko;Kagechika, Hiroyuki
• 通讯作者: Kagechika, Hiroyuki

Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia

钠钙交换器1是尿钾排泄抗急性高钾血症的关键分子

• DOI: 10.1371/journal.pone.0235360
• 发表时间: 2020
• 期刊: PLoS One.
• 作者: Shoda W;Nomura N;Ando F;Tagashira H;Iwamoto T;Ohta A;Isobe K;Mori T;Susa K;Sohara E;Rai T;Uchida S.
• 通讯作者: Uchida S.