Proposing new treatment options for cutaneous lymphomas based on the comprehensive analysis of the pathogenesis of the diseases

综合分析皮肤淋巴瘤发病机制提出新的治疗方案

• 批准号: 20K08683
• 负责人: Miyagaki Tomomitsu
• 金额: $ 2.75万
• 依托单位: St. Marianna University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K08683/
• 关键词: 皮膚悪性リンパ腫; Cyclophilin A; CD147; IL-34; PD-1; 自己分泌因子; 腫瘍微小環境; 免疫チェックポイント分子; PD-L1; VISTA; LAG-3; CSF-1R; cyclophilin A; 皮膚T細胞リンパ腫

项目成果

Poor prognostic factors of Sezary syndrome: A retrospective single‐center study from Japan

Sezary 综合征的不良预后因素：来自日本的回顾性单中心研究

• DOI: 10.1002/cia2.12241
• 发表时间: 2022
• 期刊: Journal of Cutaneous Immunology and Allergy
• 影响因子: 1
• 作者: Mizuno Yuka;Miyagaki Tomomitsu;Suga Hiraku;Kamijo Hiroaki;Boki Hikari;Kawana Yuki;Oka Kenta;Hisamoto Teruyoshi;Oka Tomonori;Takahashi‐Shishido Naomi;Sugaya Makoto;Sato Shinichi
• 通讯作者: Sato Shinichi

Decreased keratinocyte Proline‐Rich protein expression in cutaneous T‐cell lymphoma

皮肤 T 细胞淋巴瘤中角质形成细胞富含脯氨酸蛋白表达减少

• DOI: 10.1002/cia2.12240
• 发表时间: 2022
• 期刊: Journal of Cutaneous Immunology and Allergy
• 影响因子: 1
• 作者: Hisamoto Teruyoshi;Suga Hiraku;Omori Issey;Mizuno Yuka;Oka Kenta;Boki Hikari;Takahashi‐Shishido Naomi;Oka Tomonori;Miyagaki Tomomitsu;Sugaya Makoto;Sato Shinichi
• 通讯作者: Sato Shinichi

Lymphatic Dysfunction Exacerbates Cutaneous Tumorigenesis and Psoriasis-Like Skin Inflammation through Accumulation of Inflammatory Cytokines

• DOI: 10.1016/j.jid.2021.05.039
• 发表时间: 2022-05-19
• 期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY
• 影响因子: 6.5
• 作者: Boki, Hikari;Kimura, Takayuki;Sato, Shinichi
• 通讯作者: Sato, Shinichi

Increase of lymphocytes and eosinophils, and decrease of neutrophils at an early stage of anti-PD-1 antibody treatment is a favorable sign for advanced malignant melanoma

• DOI: 10.5582/ddt.2020.03043
• 发表时间: 2020-01-01
• 期刊: DRUG DISCOVERIES AND THERAPEUTICS
• 影响因子: 3.1
• 作者: Ohashi, Hiroyuki;Takeuchi, Sora;Kadono, Takafumi
• 通讯作者: Kadono, Takafumi

Exacerbated Imiquimod-Induced Psoriasis-Like Skin Inflammation in IRF5-Deficient Mice

• DOI: 10.3390/ijms21103681
• 发表时间: 2020-05
• 期刊: International Journal of Molecular Sciences
• 影响因子: 5.6
• 作者: M. Nakao;T. Miyagaki;M. Sugaya;S. Sato