Elucidation of the mechanism of CD8+ T cell exhaustion in lung cancer

阐明肺癌中 CD8 T 细胞耗竭的机制

• 批准号: 20K08531
• 负责人: Nishinakamura Hitomi
• 金额: $ 2.58万
• 依托单位: National Cancer Center Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K08531/
• 关键词: T細胞の活性化; T細胞の疲弊化; 転写因子; 疲弊化; 活性化; 活性化と疲弊化; 腫瘍免疫

项目成果

The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

• DOI: 10.1038/s41590-020-0769-3
• 发表时间: 2020-08-31
• 期刊: NATURE IMMUNOLOGY
• 影响因子: 30.5
• 作者: Kumagai, Shogo;Togashi, Yosuke;Nishikawa, Hiroyoshi
• 通讯作者: Nishikawa, Hiroyoshi

HLA Class I Analysis Provides Insight Into the Genetic and Epigenetic Background of Immune Evasion in Colorectal Cancer With High Microsatellite Instability

• DOI: 10.1053/j.gastro.2021.10.010
• 发表时间: 2022-02-21
• 期刊: GASTROENTEROLOGY
• 影响因子: 29.4
• 作者: Kawazu, Masahito;Ueno, Toshihide;Mano, Hiroyuki
• 通讯作者: Mano, Hiroyuki

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

• DOI: 10.1016/j.ccell.2022.01.001
• 发表时间: 2022-02-14
• 期刊: CANCER CELL
• 影响因子: 50.3
• 作者: Kumagai, Shogo;Koyama, Shohei;Nishikawa, Hiroyoshi
• 通讯作者: Nishikawa, Hiroyoshi