人工知能を用いた肥大型心筋症患者の収縮能低下および拡張相移行への予測

使用人工智能预测肥厚型心肌病患者收缩力下降和舒张期过渡

• 批准号: 21K08138
• 负责人: 高野 仁司
• 金额: $ 2.58万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K08138/
• 关键词: 肥大型心筋症; 心不全; 人工知能; 自動診断; 肥大型心筋症; 心不全; 人工知能; 自動診断

Background: Some patients with hypertrophic cardiomyopathy (HCM) progress to the dilated phase of HCM (DHCM). We aimed to identify the predictive factors for the development of DHCM (left ventricular ejection fraction (LVEF) < 50%) or declined LV contraction (LVEF < 60%) in patients with HCM.Methods: We analyzed the data of 291 patients who were enrolled in our hospital’s HCM registry. The patients were divided into three groups based on their LVEF at the end of the study (LVEF remained > 60%, LVEF 50-60%, and DHCM < 50%). We evaluated the predictive factors of LVEF less than 50% and 60%. We also looked at how percutaneous transluminal septal myocardial ablation (PTSMA) affected long-term systolic LV function and DHCM development.Results: During the follow-up period (mean, 71.8 months), LVEF remained > 60% in 239 patients, fell within the range of 50%-60% in 33 patients, and declined below 50% in 19 patients. Multivariate analyses indicated baseline atrial fibrillation (AF), non-sustained ventricular tachycardia (NSVT), left ventricular diameter at end-systole (LVDs) and C-reactive protein (CRP) as the significant predictors of DHCM and reduced estimated glomerular filtration rate as a nearly significant predictor for the declined LV contraction. PTSMA, performed in 78 HCM patients, did not significantly affect the long-term LVEF changes or the development of DHCM.Conclusion: We concluded that AF, NSVT, LVDs and CRP are significant predictors of DHCM development. However, a validation study with a larger population is warranted.

背景：一些患有肥厚性心肌病（HCM）的患者发展到HCM（DHCM）的扩张期。我们的目的是确定HCM.Methods患者的DHCM（左心室发射分数（LVEF）<50％）或LV收缩（LVEF <60％）的预测因素：我们分析了291名在我们医院HCM摄入率的患者的数据。在研究结束时，根据其LVEF将患者分为三组（LVEF保持> 60％，LVEF 50-60％，DHCM <50％）。我们还研究了经皮易感中膜心肌消融（PTSMA）如何影响长期收缩期LV功能和DHCM的发育。回报：在后续期间（平均71.8个月，71.8个月），LVEF在239名患者中> 60％> 60％，在33名患者中降落在33名患者的范围​​内，在以下50％的患者中降落在50％的患者中。多变量分析表明基线房颤（AF），非固定心室心动过速（NSVT），末端 - 螺旋杆（LVD）（LVD）和C-反应蛋白（CRP）的左心直径（CRP）是DHCM的重要预测因子，并且是DHCM的重要预测指标，并且几乎是估计的估计性估计的预测速率，几乎是一个有效的预测速率。 PTSMA在78例HCM患者中进行，并未显着影响LVEF的长期变化或DHCM的发展：我们得出的结论是，AF，NSVT，LVD和CRP是DHCM开发的重要预测指标。但是，有必要进行较大人口的验证研究。