The More the Merrier? Investigating copy number variation in Brassicas

多多益善？

• 批准号: DP160104497
• 负责人: Prof Jacqueline Batley
• 金额: $ 30.34万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160104497
• 关键词: More; Merrier; Investigating; copy; number

This project intends to develop an understanding of how gene copy number variation affects disease susceptibility to help in the design of novel plant protection strategies. Gene copy number variants (CNVs) are segments of DNA that have been duplicated or lost in the genome of one individual or line with respect to another. CNVs have been shown to contribute significantly to phenotypic differences in humans, including disease susceptibility, and the same seems to apply in plants. This project aims to apply the genome sequences for Brassica species to detect CNVs from re-sequencing data. Knowing how this variation affects an individual or line’s disease susceptibility, especially to the devastating fungal pathogen blackleg, could improve plant protection strategies and crop production.

该项目旨在深入了解基因拷贝数变异如何影响疾病易感性，以帮助设计新型植物保护策略。基因拷贝数变异 (CNV) 是个体基因组中重复或丢失的 DNA 片段。已证明 CNV 对人类的表型差异（包括疾病易感性）有显着影响，这似乎也适用于植物。该项目旨在应用芸苔属物种的基因组序列来检测 CNV。了解这种变异如何影响个体或品系的疾病易感性，特别是对毁灭性真菌病原体黑胫病的易感性，可以改善植物保护策略和作物生产。