Die circannuale Uhr, ihre Lokalisation und Synchronisation

昼夜时钟、其定位和同步

• 批准号: 26682976
• 负责人: Dr. Stefanie Monecke
• 金额: --
• 依托单位: Institut für Medizinische Psychologie
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/26682976?language=en
• 关键词: Die; circannuale; Uhr; ihre; Lokalisation

The aim of this project is to 1) localize the circannual clock, to investigate 2) the possibility that the circannual clock might get photoperiodic information by other pathways than melatonin and 3) the particularities of photoperiodic time measurement in the field. My model species is the circannual European hamster whose circannual driven changes in the daily activity pattern characterize an annual phase of sensitivity to short photoperiods. Thus, at the beginning and the end of the sensitive phase the circadian and the circannual clock communicate and the brain areas that form the circannual clock should show a different metabolism than at other times of year. To visualize this the functional magnetic resonance imaging technique will be adapted to European hamsters with the aim to localize the circannual clock. Recent studies suggested that in European hamsters not only melatonin mediates photoperiodic information to the circannual clock. To test this, pinealectomized animals will be subjected to an exotic photoperiodic cycle. A synchronization would prove the existence of such a pathway, which then will be explored. A third study will address the question of the decline of European hamsters in Western Europe where females have too few litters per year to ensure the continuity of the population. This might be due to a major delay in emergence from hibernacula and thus due to a misaligned circannual clock. In outdoor enclosures, recording techniques will be developed to examine photoperiodic time measurement in the field.

该项目的目的是 1) 定位生物钟，研究 2) 生物钟可能通过褪黑激素以外的其他途径获取光周期信息的可能性，以及 3) 现场光周期时间测量的特殊性。我的模型物种是一年一度的欧洲仓鼠，其每日活动模式的每年驱动变化表征了每年对短光周期敏感的阶段。因此，在敏感阶段的开始和结束时，昼夜节律和生物钟进行交流，形成生物钟的大脑区域应该表现出与一年中其他时间不同的新陈代谢。为了形象化这一点，功能性磁共振成像技术将适用于欧洲仓鼠，目的是定位昼夜节律。最近的研究表明，在欧洲仓鼠中，不仅褪黑激素将光周期信息传递给生物钟。为了测试这一点，松果体切除的动物将接受奇异的光周期循环。同步将证明这样一条路径的存在，然后将对其进行探索。第三项研究将解决西欧欧洲仓鼠数量减少的问题，因为西欧雌性每年产仔数太少，无法确保种群的连续性。这可能是由于冬眠出现的时间大大延迟，从而导致生物钟错位。在室外围栏中，将开发记录技术来检查现场的光周期时间测量。