NSF Convergence Accelerator Track L: An Integrated and Miniaturized Opioid Sensor System: Advancing Evidence-Based Strategies for Addressing the Opioid Crisis

NSF 融合加速器轨道 L：集成和小型化阿片类药物传感器系统：推进解决阿片类药物危机的循证策略

• 批准号: 2344344
• 负责人: Xinyu Zhang
• 金额: $ 64.96万
• 依托单位: Auburn University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-01-15 至 2024-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2344344&HistoricalAwards=false
• 关键词: NSF; Convergence; Accelerator; Track; Integrated

This research addresses the pressing public health challenge of the opioid crisis through the development of innovative, cost-efficient, portable opioid biosensors. The interdisciplinary team, comprising experts from academia, industries, healthcare, and governments, aims to deliver real-world solutions to combat the opioid epidemic. The project's importance lies in its potential to provide immediate, accurate opioid detection and monitoring, which is crucial for effective law enforcement, precise medicine and treatment, and environmental monitoring. This technology aligns with NSF's mission by contributing to the advancement of science, promoting national health, and enhancing public welfare. The broader impacts of this initiative include raising public awareness about opioid risks, fostering educational opportunities in science and technology, and developing a skilled workforce. The project aims to create a paradigm shift in opioid crisis management, offering tangible solutions that can reduce opioid misuse, enhance public safety, and inform effective policy-making. Additionally, it addresses societal needs, including promoting public education on opioid risks and fostering technological and scientific workforce development. The project centers on the creation of a novel opioid biosensor technology, named iM-Dr (inter-Molecular Interaction-enabled Detective Recognition), offering advancements such as high sensitivity, selectivity and versatility. Various forms of biosensors, including handheld probes, test strips, and wearable patches, are being developed to cater to diverse applications. The project incorporates cutting-edge sensor materials, artificial intelligence integration, and comprehensive social impact studies. The project also aims for scalability to ensure widespread accessibility and integration into different sectors of society. The expected outcome is a significant reduction in opioid-related incidents and deaths, an increase in public awareness, and an enhanced framework for research and policy development addressing the opioid crisis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项研究通过开发创新、经济高效的便携式阿片类生物传感器来解决阿片类药物危机所带来的紧迫的公共卫生挑战。这个跨学科团队由来自学术界、工业界、医疗保健和政府的专家组成，旨在提供实际的解决方案来对抗阿片类药物的流行。该项目的重要性在于其提供即时、准确的阿片类药物检测和监测的潜力，这对于有效的执法、精准的药物和治疗以及环境监测至关重要。这项技术与 NSF 的使命相一致，即为科学进步、促进国民健康和增强公共福利做出贡献。该倡议的更广泛影响包括提高公众对阿片类药物风险的认识、促进科学技术教育机会以及培养熟练的劳动力。该项目旨在实现阿片类药物危机管理的范式转变，提供切实的解决方案，以减少阿片类药物滥用、增强公共安全并为有效的决策提供信息。此外，它还满足社会需求，包括促进有关阿片类药物风险的公众教育以及促进技术和科学劳动力的发展。该项目的重点是创建一种名为 iM-Dr（分子间相互作用的侦探识别）的新型阿片类生物传感器技术，该技术具有高灵敏度、选择性和多功能性等优点。人们正在开发各种形式的生物传感器，包括手持式探针、测试条和可穿戴贴片，以满足不同的应用需求。该项目融合了尖端传感器材料、人工智能集成和全面的社会影响研究。该项目还旨在实现可扩展性，以确保广泛的可访问性和融入社会不同部门。预期成果是阿片类药物相关事件和死亡显着减少、公众意识提高以及解决阿片类药物危机的研究和政策制定框架得到加强。该奖项反映了 NSF 的法定使命，并通过评估认为值得支持利用基金会的智力优势和更广泛的影响审查标准。