MRI: Track 1: Acquisition of a Gas Chromatography-Mass Spectrometer for Advancing Research and Education at Montclair State University

MRI：轨道 1：采购气相色谱-质谱仪以推进蒙特克莱尔州立大学的研究和教育

• 批准号: 2320458
• 负责人: Jaclyn Catalano
• 金额: $ 17.21万
• 依托单位: Montclair State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320458&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; Gas; Chromatography

This award is funded by the Major Research Instrumentation Program and the Chemistry Research Instrumentation Program. Montclair State University is acquiring a Gas Chromatography-Mass Spectrometer with a pyrolysis unit (Py-GC/MS) to support Professor Jaclyn Catalano and colleagues Nathanael Hirscher, Nina Goodey, Jinshan Gao, Meiyin Wu, and 11 additional faculty members in three departments across the university. This instrument allows for routine separation of liquid and solid samples with high sensitivity and detection of mass to charge ratios. This versatile instrumental setup allows for different sample types encompassing the broad research and teaching needs of the College of Science and Mathematics at Montclair State University. The instrument will be used by the diverse undergraduate and graduate student population performing research. The instrument will be incorporated into coursework pertaining to seven different academic majors and will be used by up to 300 students annually, providing undergraduates with essential research skills for jobs and/or preparing them for professional schools. Programs will be established to include the instrumentation in pre-college student outreach programs.The award is aimed to use the Py-GC/MS instrument to enhance and supplement current ongoing research projects in the fields of biochemistry, analytical, inorganic, and soil chemistry and environmental science. Py-GC/MS is a versatile instrument, capable of analyzing chemical mixtures in the solid (via pyrolysis) or liquid/gas (via standard injection) phase. This allows this instrument to be used by various researchers in different departments on a variety of samples from soils to organic compounds. Multiple research projects will be enhanced by this instrument, including (1) discovery and development of more specific non toxic drugs to be activated (made toxic) by a specific enzyme; (2) evaluation of soil remediation strategies by using artificial root exudate solution to initiate degradation of carcinogenic and toxic polycyclic aromatic hydrocarbons. This is especially important because these toxins are environmentally stable, resistant to degradation, and generally persist in the environment for long periods of time; (3) determination of the reaction intermediates for the synthesis of glycan standards and free radical tags, which will benefit the development of novel free radical tags for glycan quantitation and characterization; (4) synthesizing and testing novel organometallic catalysts for reactions of hydrocarbons and other organic substrates, controlled by tailored organic ligands; (5) assessment of the environmental contaminants in the New York-New Jersey metropolitan area and to investigate human seafood consumption safety. The results will be used to formulate data-driven policy recommendations to safeguard human health. In addition, undergraduates and graduate students will be trained on the instrument as part of their research projects and/or academic coursework.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由重大研究仪器计划和化学研究仪器计划资助。蒙特克莱尔州立大学正在购买一台带有热解装置 (Py-GC/MS) 的气相色谱-质谱仪，以支持 Jaclyn Catalano 教授及其同事 Nathanael Hirscher、Nina Goodey、Jinshan Gau、Meiyin Wu 以及三个系的另外 11 名教职人员大学。该仪器可以高灵敏度地常规分离液体和固体样品并检测质荷比。这种多功能仪器设置允许不同的样品类型，涵盖蒙特克莱尔州立大学科学与数学学院广泛的研究和教学需求。该仪器将供不同的本科生和研究生群体进行研究。该工具将被纳入七个不同学术专业的课程作业中，每年将有多达 300 名学生使用，为本科生提供就业所需的基本研究技能和/或为他们进入专业学校做好准备。将设立一些计划，将仪器纳入大学预科学生的推广计划中。该奖项旨在使用 Py-GC/MS 仪器来增强和补充当前在生物化学、分析、无机和土壤化学领域正在进行的研究项目和环境科学。 Py-GC/MS 是一种多功能仪器，能够分析固相（通过热解）或液/气相（通过标准进样）的化学混合物。这使得不同部门的不同研究人员可以使用该仪器来处理从土壤到有机化合物的各种样品。该仪器将增强多个研究项目，包括（1）发现和开发更特定的无毒药物，由特定的酶激活（使其有毒）； (2)利用人工根系分泌液降解致癌、有毒多环芳烃的土壤修复策略评价。这一点尤其重要，因为这些毒素对环境稳定、不易降解，并且通常会在环​​境中长期存在； （3）确定用于合成聚糖标准品和自由基标签的反应中间体，这将有利于开发用于聚糖定量和表征的新型自由基标签； （4）合成和测试用于碳氢化合物和其他有机底物反应的新型有机金属催化剂，由定制的有机配体控制； （5）评估纽约-新泽西都会区环境污染物并调查人类海鲜消费安全。研究结果将用于制定数据驱动的政策建议，以保障人类健康。此外，本科生和研究生将接受该仪器的培训，作为其研究项目和/或学术课程的一部分。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。