Collaborative Research: Bioarchaeology, Osteoimmunology, and Ecoimmunology: Linking Inflammation, Life History Tradeoffs, and Biocultural Change

合作研究：生物考古学、骨免疫学和生态免疫学：将炎症、生活史权衡和生物文化变革联系起来

• 批准号: 2316572
• 负责人: Haagen Klaus
• 金额: $ 14万
• 依托单位: George Mason University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2316572&HistoricalAwards=false
• 关键词: Collaborative; Research; Bioarchaeology; Osteoimmunology; Ecoimmunology

The immune system and the skeleton are often viewed as separate parts of our biology. However, recent research has revealed that the skeletal and immune systems interact more than previously appreciated as part of the “osteoimmune” system. Hyperinflammation experienced earlier in life, which can result in chronic inflammation, therefore affects the skeleton as well as other parts of the body. This project examines immune and inflammatory proteins in bone that are markers of this complex relationship between bone and immune function and applies them to questions about biocultural processes in human societies. The project advances knowledge in skeletal biology and bioarchaeology by combining traditional observations of skeletal pathology with proteomic analysis to better identify inflammatory responses that may be shaping human morbidity and mortality in the past and present. The broader impacts of the project include student training, including individuals from groups underrepresented in STEM; curriculum expansion; international research collaborations; and engagement with schools, communities, and the public. Early life biological stress and immune system over-activation are thought to produce cascading effects involving phenotypic plasticity and life history trade-offs that shape predilections for later-life inflammatory and hyperinflammatory phenotypes. This project pursues a cross-disciplinary study of skeletal inflammatory diseases, combining observations of periodontal disease and periosteal reaction with proteomic analyses of at least of four independent inflammatory protein biomarkers (osteocalcin, macrophage inflammatory proteins, leukocyte-derived proteins, and neutrophil-derived proteins) in individuals possessing an inferred hyperinflammatory phenotype. The PIs address biocultural hypotheses about the co-occurrence of pathological processes, the role of early life environments in shaping immune response, and the influence of sociocultural dynamics on human biology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

免疫系统和骨骼通常被视为我们生物学的独立部分，然而，最近的研究表明，骨骼和免疫系统之间的相互作用比以前认为的“骨免疫”系统的一部分要多，这可能会导致生命早期发生过度炎症。导致慢性炎症，因此影响骨骼以及身体的其他部位。该项目检查骨骼中的免疫和炎症蛋白，这些蛋白是骨骼和免疫功能之间复杂关系的标志，并将它们应用于有关人类社会生物文化过程的问题。 .项目进展顺利通过将骨骼病理学的传统观察与蛋白质组学分析相结合，更好地识别可能影响过去和现在人类发病率和死亡率的炎症反应，该项目的更广泛影响包括学生培训，包括来自代表性不足群体的个人。 STEM 课程扩展；以及与学校、社区和公众的接触，这些因素被认为会产生连锁效应和表型可塑性。影响晚年炎症和高炎症表型倾向的生活史权衡 该项目致力于骨骼炎症疾病的跨学科研究，将牙周病和骨膜反应的观察与至少四种独立炎症蛋白生物标志物的蛋白质组学分析相结合。 （骨钙素、巨噬细胞炎症蛋白、白细胞衍生蛋白和中性粒细胞衍生蛋白）具有推断的高炎症表型的个体。关于病理过程同时发生、早期生活环境在形成免疫反应中的作用以及社会文化动态对人类生物学的影响的生物文化假设。该奖项反映了 NSF 的法定使命，并通过使用基金会的评估进行评估，认为值得支持。智力价值和更广泛的影响审查标准。