SBIR Phase I: Consortium for High Throughput CubeLab by Space Tango

SBIR 第一阶段：Space Tango 高通量 CubeLab 联盟

• 批准号: 2416101
• 负责人: Twyman Clements
• 金额: $ 27.49万
• 依托单位: SPACE TANGO LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-03-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2416101&HistoricalAwards=false
• 关键词: SBIR; Phase; Consortium; Throughput; CubeLab

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to address some of the most impactful health research questions by using high throughput techniques in the weightless environment of Low Earth Orbit (LEO). When studying diseases or developing treatments on Earth, cellular models are often used to “stand in” for humans during the development phase because of the high number of trials that can be performed in a short period of time. The microgravity environment offered in LEO, provides a unique laboratory where some diseases can be studied more efficiently than on the ground. This project’s technology is being developed to allow for an unprecedented number of samples to be studied in space, and making world-class health research finally achievable by providing the statistical significance that could only be achieved on Earth. The consortium being formed brings us together with a group of world-class researchers in fields such as cancer research and drug delivery. Beyond potential health impacts, these studies will encourage the small businesses involved to develop products and strategies for the future, both on Earth and in space.This Small Business Innovation Research (SBIR) Phase I project will double the current capacity of a biological platform technology to enable nearly 600 individual samples in one payload. All samples will be hosted in an environmentally-controlled, sealed system, matching the best incubation conditions available on Earth, and flown in space during this Phase I project for 30 days on the International Space Station (ISS). This high throughput system will allow for numerous start-ups and labs, including collaborators from Notre Dame, the University of San Diego, Mithrilome, Encapsulate, Massachusetts General Hospital, and Mount Sinai Icahn School of Medicine. These collaborators will fly specialized cells, groups of cells, and nanomaterials to screen for the best candidates in which to target further translational research and commercialization efforts. Enough statistical evidence will be gathered to match the quality of any ground-based study that could be carried out. The members of the consortium will carry out research related to Rett syndrome, Alzheimer’s disease, biomanufacturing of health-related products, drug delivery formulations, brain cancer, gastrointestinal cancer therapies, and the heart.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）I阶段项目的更广泛的影响/商业潜力是通过在低地球轨道（LEO）失重环境中使用高吞吐量技术来解决一些最有影响力的健康研究问题。在研究疾病或在地球上开发治疗方法时，由于可以在短时间内进行的试验数量大量，因此通常会使用细胞模型为人类“站立”。狮子座提供的微重力环境提供了一个独特的实验室，其中一些疾病可以比地面更有效地研究。正在开发该项目的技术，以允许在太空中进行空前的样本数量，并通过提供只能在地球上实现的统计意义来最终实现世界一流的健康研究。组成的财团将我们与癌症研究和药物递送等领域的一群世界一流的研究人员一起。除了潜在的健康影响之外，这些研究还将鼓励所涉及的小型企业在地球和太空中开发未来的产品和策略。这项小型企业创新研究（SBIR）I阶段项目将使生物平台技术的当前能力增加一倍，以使一个有效载荷中近600个单独的样本。所有样品将托管在环境控制的密封系统中，匹配地球上最佳的孵化条件，并在此阶段I项目中在太空中飞行30天在国际空间站（ISS）。这种高吞吐量系统将允许许多初创企业和实验室，包括巴黎圣母院，圣地亚哥大学，Mithrilome，封装，马萨诸塞州综合医院和西奈山伊卡恩医学院的合作者。这些合作者将飞行专业的细胞，细胞组和纳米材料，以筛选最佳候选者，以瞄准进一步的转化研究和商业化工作。将收集足够的统计证据，以匹配任何可以进行的地面研究的质量。该联盟的成员将进行与RETT综合征，阿尔茨海默氏病，与健康相关产品的生物制造，药物输送配方，脑癌，胃肠道癌疗法和心脏的研究。这奖反映了NSF的立法任务，并通过评估通过基金会的知识优点和广泛的评估来评估，并被认为是宝贵的。