PFI-TT: Expanding the Market Share of Domestically Produced Primary Phosphines

PFI-TT：扩大国产原生膦市场份额

• 批准号: 2329625
• 负责人: Rory Waterman
• 金额: $ 54.54万
• 依托单位: University of Vermont & State Agricultural College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2329625&HistoricalAwards=false
• 关键词: PFI; TT; Expanding; Market; Share

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project is the support for the economic development resulting from a diversified chemical feedstock. Primary phosphines, organophosphorus compounds containing a single organic substituent, are important chemical precursors. Their use can benefit agriculture, biomedicine, materials science, and consumer goods by supporting efficient preparation of a wide range of known, useful products that benefit society as well as to help develop new products. Current technology that produces primary phosphines is highly wasteful and hazardous. This project’s technology provides these products with increased safety and reduced waste, which can expand domestic chemical production. This project leverages catalysis and supports further growth of this environmentally friendly, multi-billion-dollar industry. The project team has a strong record of involving individuals from marginalized identities in science to expand the future STEM workforce. Such efforts will continue to serve national and state workforce development goals. Additionally, part of this project will aid in the long-term development of entrepreneurship education to yield regional students who will be better prepared for technology transfer and conversion of science to market-ready products in the future. The proposed project seeks to transition an NSF-funded discovery to a viable marketplace technology. To meet this goal, Lewis acid catalysis will be used to prepare primary phosphines. Lewis acid catalysis has become a topic of tremendous interest including recognition by the 2022 Nobel Prize in Chemistry. Application of these cutting-edge discoveries will address the key challenge in primary phosphine synthesis, which is to move away from hazardous metal-based reducing agents. Goals of the project include expansion of the primary phosphines that can be prepared by this method, exploration of alternative catalysts including solid state catalysts, and preparations for growth to pilot scale production. The applied research plan directly addresses the more practical utilization of Lewis acid catalysis in the preparation of value-added products. The project aims to support new technology and new products in the marketplace. In meeting these goals, opportunities for Lewis acid catalysis in the preparation of commodity chemicals will be expanded through a greater understanding of their reactivity, especially at scale. The ability to utilize alternative Lewis acids would also be realized through this project, and additional aspects of phosphorus chemistry will be understood.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这种创新合作伙伴关系的更广泛的影响/商业潜力 - 技术翻译（PFI -TT）项目是支持由多元化的化学原料产生的经济发展的支持。原代磷，有机磷的有机磷化合物是重要的化学前体。它们的使用可以通过支持有效制备各种已知的有用的产品，从而使社会和开发新产品有效地制定有效制备，从而使农业，生物医学，材料科学和消费品受益。当前产生原磷的技术是高度浪费和危险的。该项目的技术为这些产品提供了增加的安全性和减少的废物，从而可以扩大国内化学生产。该项目利用催化，并支持这个环保，数十亿美元的行业的进一步增长。项目团队的参与记录很强。从科学中边缘化身份的个人扩大未来的STEM劳动力。这样的努力将继续为国家和州劳动力发展目标提供服务。此外，该项目的一部分将有助于长期发展企业家教育，以产生将来将为科学转换和将科学转换为市场就绪产品的区域学生。拟议的项目旨在将NSF资助的发现过渡到可行的市场技术。为了满足这一目标，路易斯酸催化将用于制备原发磷。路易斯酸催化已成为引起极大兴趣的话题，包括2022年诺贝尔化学奖的认可。这些尖端发现的应用将解决原代磷酸合成的关键挑战，即偏离危险金属的还原剂。该项目的目标包括可以通过这种方法制备的主要磷的扩展，探索包括固态催化剂在内的替代催化剂，以及为生长量表生产的准备。应用研究计划直接解决了刘易斯酸催化在制备增值产品中的更实际利用。该项目旨在支持市场上的新技术和新产品。在实现这些目标时，将通过对它们的反应性有更大的了解，尤其是在规模上的反应性来扩大刘易斯酸催化剂在制备商品化学品制备中的机会。利用替代刘易斯酸的能力也将通过该项目实现，并且将理解磷化学的其他方面。该奖项反映了NSF的法定任务，并通过使用该基金会的智力优点和更广泛的影响来审查标准，认为通过评估，认为这是宝贵的支持。