I-Corps: Long-Term, User-Friendly, and Motion-Artifact-Free Heart Monitoring

I-Corps：长期、用户友好且无运动伪影的心脏监测

• 批准号: 2328471
• 负责人: Zheng Yan
• 金额: $ 5万
• 依托单位: University of Missouri-Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2328471&HistoricalAwards=false
• 关键词: Corps; Long; Term; User; Friendly

The broader impact/commercial potential of this I-Corps project is focused on improving the wearable heart monitor’s long-term biocompatibility and long-lasting fidelity of signal recording. Heart diseases, the leading cause of mortality in the United States, contribute to nearly 655,000 deaths each year and approximately $219 billion annual healthcare cost. Continuous, long-term electrocardiogram monitoring outside clinical settings is critical for early detection and timely intervention of a variety of heart conditions. However, current wearable heart monitors usually suffer from limited long-term biocompatibility and motion-induced artifacts, constraining their efficiency. Recently developed, porous wearable heart monitors can surmount these limitations and improve the quality of life for those afflicted with diverse heart conditions. This project aims to assess the potential of this new technology to spawn new business opportunities. The planned commercialization path, including founding a start-up or licensing the technology to interested third parties, offers promise for contributing to economic development and creation of new jobs. Additionally, this project can also enhance scientific and technological understanding in the field of biomedical monitoring and holds potential to catalyze progress in healthcare technology.This I-Corps project is based on the development of a new porous wearable heart monitor, which can simultaneously achieve ultrasoftness, high breathability, outstanding antimicrobial property, thermal regulation, and strain-insensitive electrical performance. Ultrasoftness can mitigate skin irritation and promote seamless device-skin integration. High breathability can help to reduce the likelihood of inflammation and data loss caused by sweat accumulation. The antimicrobial feature can prevent infections from foreign pathogenic microbes, a particularly crucial attribute for home-based applications. Thermal regulation can avoid potential skin burns from wearable circuits and mitigate the effect of temperature changes on device performance. Strain-insensitive electrical performance can minimize artifacts caused by human motions. The integration of these unique features can facilitate the creation of motion-artifact-free wearable heart monitors with unprecedented long-term biocompatibility and user-friendliness. Besides, additive manufacturing is employed in device fabrication to ensure cost-effectiveness. Moreover, beyond heart monitors, this technique can be harnessed to build a range of customized wearable devices with long-term biocompatibility and long-lasting fidelity of biosignal recording to satisfy a variety of arising requirements of home-based, personalized healthcare.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力集中在改善可穿戴心脏监护仪的长期生物相容性和信号记录的持久忠诚度。心脏病是美国死亡率的主要原因，每年造成近65.5万人死亡，每年约219亿美元的医疗保健费用。连续的，长期的心电图监测在临床环境外部对于早期检测和及时干预各种心脏状况至关重要。但是，当前的可穿戴心脏监护仪通常会遭受有限的长期生物相容性和运动引起的伪影，从而限制了它们的效率。最近开发的多孔可穿戴心脏监视器可以克服这些局限性，并改善患有潜水心脏病的人的生活质量。该项目旨在评估这项新技术产生新商机的潜力。计划中的商业化路径，包括建立初创企业或将技术许可向有趣的第三方许可，为有助于经济发展和创造新就业机会做出了希望。此外，该项目还可以增强生物医学监测领域的科学和技术理解，并具有催化医疗保健技术进展的潜力。该I-Corps项目基于开发新的多孔可穿戴心脏监护仪，该项目可以轻松实现Ultrasoftness，高透气性，高透气，出色的抗药性抗药性，热调节，菌株和应变型电子性能。 Ultrasoftness可以减轻皮肤刺激并促进无缝的设备皮肤集成。高透气性可以帮助减少因汗水积累引起的感染和数据丢失的可能性。抗微生物特征可以防止外来病原微生物感染，这是家庭基于家庭应用的特别关键属性。热调节可以避免可穿戴电路的潜在皮肤燃烧，并减轻温度变化对设备性能的影响。不敏感的电性能可以最大程度地减少由人类运动引起的伪影。这些独特功能的整合可以支持创建没有前所未有的长期生物相容性和用户友好性的无运动耐磨性心脏监测器。此外，设备制造中还进行了上瘾的制造，以确保成本效益。此外，除了心脏监护仪之外，可以利用该技术建立一系列具有长期生物相容性和长期生物信号记录的忠诚度的定制可穿戴设备，以满足基于家庭的个性化医疗保健的各种要求。该奖项对NSF的法定任务进行了评估，反映了通过评估商标的支持。