Collaborative Research: IHBEM: Multidisciplinary Analysis of Vaccination Games for Equity (MAVEN)

合作研究：IHBEM：疫苗公平博弈的多学科分析 (MAVEN)

• 批准号: 2327790
• 负责人: Dewey Taylor
• 金额: $ 66.64万
• 依托单位: Virginia Commonwealth University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2327790&HistoricalAwards=false
• 关键词: Collaborative; Research; IHBEM; Multidisciplinary; Analysis; Collaborative; Research; IHBEM; Multidisciplinary; Analysis

The MAVEN (Multidisciplinary Analysis of Vaccination Games for Equity) project addresses the global health threat of vaccine inequity in the fight against emerging infectious diseases. This project aims to provide a comprehensive understanding of vaccination coverage and identify key drivers of vaccine uptake. This will reduce the risk of future pandemics by enabling targeted interventions to increase vaccine acceptance among vulnerable populations, in particular racial/ethnic/sexual minority and rural populations. The research will also help to address vaccine inequities in the United States that are currently disproportionately affecting minority subgroups and clinical subpopulations (e.g., men with HIV infection). Ultimately, this research will have implications for public health policy and practice, contributing to the global effort to predict and mitigate the impacts of pandemics. In addition to the scientific contributions, the project will provide valuable training opportunities for over ninety undergraduate and graduate students and cultivate a diverse pool of talent equipped to adequately respond to current and future pandemics.The project will answer three questions: Q1) What are the structural, social, and individual factors related to vaccine uptake for common diseases (e.g., influenza), newer pandemics/epidemics, e.g., COVID-19, mpox (monkeypox), and future diseases? Q2) How does population heterogeneity affect vaccination behavior in a community context? Q3) How does individual behavior feedback into mpox (monkeypox) disease dynamics? The project will combine expertise from mathematical epidemiology and social and behavioral sciences to (1) develop a general framework of vaccine uptake that incorporates individual, social, and structural factors by analyzing a variety of secondary datasets, (2) collect primary survey data and use the framework to develop universal vaccine uptake (as well as vaccine refusal) models that are broadly applicable to mpox (monkeypox) and future outbreaks, and (3) use traditional and modern economic models of individual decision-making under uncertainty. Methodologically, the project will develop a new epidemiological-behavioral system of ordinary differential equations, using multiple data sources (observational, survey, and experimental) and mixed methods to estimate people’s vaccination preferences. The project will also integrate the investigators' empirical findings into the new epi-model, and use the parameterized epi-model to conduct retrospective and prospective vaccine acceptance and hesitance/refusal models.This award is jointly funded by the Division of Mathematical Sciences and the Division of Social and Economic Sciences in the Directorate of Social, Behavioral and Economic Sciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

Maven（公平疫苗接种游戏的多学科分析）项目涉及疫苗在抵抗紧急疾病的斗争中的全球健康威胁。该项目旨在全面了解疫苗覆盖范围，并确定疫苗摄取的关键驱动因素。这将通过使有针对性的干预措施增加弱势群体的疫苗接受，尤其是种族/种族/性少数群体和粗糙的人口，从而降低未来大流行的风险。这项研究还将有助于解决美国目前对少数族裔亚组和临床亚群体（例如，患有HIV感染的男性）的疫苗不平等。最终，这项研究将对公共卫生政策和实践产生影响，这有助于全球预测和减轻大流行的影响的努力。除科​​学贡献外，该项目还将为90多名本科生和研究生提供宝贵的培训机会，并培养潜水者的人才库，等同于充分回应当前和未来的大流行病。该项目将回答三个问题：Q1）结构，社会和个人因素是什么是与常见疾病相关的个人因素是什么，例如常见疾病（例如），例如（例如，exemics）。 COVID-19，MPOX（Monkeypox）和未来疾病？ Q2）人口异质性如何影响社区环境中的疫苗行为？ Q3）个人行为反馈如何反馈MPOX（Monkeypox）疾病动力学？ The project will combine expert from mathematical epidemiology and social and behavioral sciences to (1) develop a general framework of vaccine uptake that incorporates individual, social, and structural factors by analyzing a variety of secondary datasets, (2) collect primary survey data and use the framework to develop universal vaccine uptake (as well as vaccine refuse) models that are broadly applicable to mpox (monkeypox) and future outbreaks, and （3）在不确定性下使用个人决策的传统和现代经济模型。从方法上讲，该项目将使用多个数据源（观察性，调查和实验性）和混合方法来开发一个新的普通微分方程的流行病学行为系统，以估计人们的疫苗偏好。该项目还将将调查人员的经验发现整合到新的Epi模型中，并使用参数化的Epi模型来进行回顾性和前瞻性疫苗的接受和犹豫/拒绝模型。这项奖项由数学科学和社会和经济统治的社会和经济统治局长共同资助。认为值得通过基金会的智力优点和更广泛影响的评论标准来评估值得支持。