I-Corps: Novel hydrogels for chronic diseases in pets and livestock

I-Corps：治疗宠物和牲畜慢性疾病的新型水凝胶

• 批准号: 2327750
• 负责人: Krzysztof Marycz
• 金额: $ 5万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2327750&HistoricalAwards=false
• 关键词: Corps; Novel; hydrogels; chronic; diseases

The broader impact potential of this I-Corps project is a novel approach for the treatment of oral inflammatory and ulcerative diseases in dogs and cats. As the biggest challenge with inflammatory dental disease treatment lies in biofilm reduction, anti-viral mechanisms, immune system modulation, and reduction of inflammation, our solution tackles it all with economically feasible, easy to use, and efficient technology. This innovation will stimulate stem cells to grow and promote wound healing of damaged tissue by maintaining gingival mesenchymal stem cells homeostasis. This novel approach for Feline chronic gingivostomatitis treatment with the application of Lactic Acid Bacteria-derived metabolites and exosomes combined with organic zinc nanoparticles and hydrogel in a formulation.This I-Corps project is based on the development of treatment of periodontal disease, which is the most common infectious condition in adult dogs and cats. It is a progressive, cyclical inflammatory disease of the supporting structures of the tooth and is the main cause of dental disease and early tooth loss in both species. It affects over 87% of dogs and 70% of cats over three years of age. This novel approach uses a hydrogel enriched with paraprobiotics (non-infectious microbial cell components such as peptidoglycans, teichoic acids, surface proteins, etc.) and lactic acid bacteria probiotics derived biomolecules, so-called postbiotics (exosomes, enzymes, secreted proteins, short chain fatty acids, vitamins, secreted biosurfactants, amino acids, peptides, organic acids, etc.) enhanced with biologically produced zinc oxide nanoparticles. This technology will help cats by reducing inflammation, dental plaque, chronic pain, promoting tissue and cell regeneration, treating viral infection, and improving wound healing.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

I-Corps 项目的更广泛影响潜力是一种治疗狗和猫口腔炎症和溃疡性疾病的新方法。由于炎症性牙科疾病治疗的最大挑战在于生物膜减少、抗病毒机制、免疫系统调节和减少炎症，我们的解决方案通过经济可行、易于使用和高效的技术来解决这一切。这项创新将通过维持牙龈间充质干细胞的稳态来刺激干细胞生长并促进受损组织的伤口愈合。这种治疗猫慢性龈口炎的新方法是将乳酸菌衍生的代谢物和外泌体与有机锌纳米颗粒和水凝胶结合在配方中。该 I-Corps 项目基于牙周病治疗的开发，是成年狗和猫中最常见的感染性疾病。它是一种牙齿支持结构的进行性、周期性炎症性疾病，是这两个物种的牙齿疾病和早期牙齿脱落的主要原因。它影响超过 87% 的三岁以上狗和 70% 的猫。这种新颖的方法使用富含副益生菌（非感染性微生物细胞成分，如肽聚糖、磷壁酸、表面蛋白等）和乳酸菌益生菌衍生的生物分子，即所谓的后生元（外泌体、酶、分泌蛋白、短链）的水凝胶。链脂肪酸、维生素、分泌的生物表面活性剂、氨基酸、肽、有机酸等）通过生物产生的氧化锌纳米粒子增强。该技术将通过减少炎症、牙菌斑、慢性疼痛、促进组织和细胞再生、治疗病毒感染和改善伤口愈合来帮助猫。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值进行评估，认为值得支持以及更广泛的影响审查标准。