REU Site: Comparative Animal Model Approaches to Regeneration and Aging

REU 网站：再生和衰老的比较动物模型方法

• 批准号: 2243416
• 负责人: Dustin Updike
• 金额: $ 40.97万
• 依托单位: Mount Desert Island Biological Laboratory
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2243416&HistoricalAwards=false
• 关键词: REU; Site; Comparative; Animal; Model

This REU Site award to the Mount Desert Island Biological Laboratory (MDIBL), located in Bar Harbor, ME, will support the training of 10 students for 10 weeks during the summers of 2023-2025. It is anticipated that a total of 30 students, primarily from schools with limited research opportunities or from underrepresented groups, will be trained in the program. Students will be at all stages of their undergraduate studies, and special consideration will be given to applicants interested in microscopy and comparative animal model research on regeneration and aging. Students will learn how research is conducted, and many will present the results of their work at scientific conferences. Assessment of the program will be done through the online SALG URSSA tool. Students will be required to register in the NSF ETAP system (etap.nsf.gov) and tracked after the program to determine their career paths.This REU program MDIBL will expose students to comparative animal model approaches used to understand the biology of regeneration and aging. Labs at this REU site are interested in how cells, tissues, organs, and limbs are repaired or replenished after injury or during the ordinary course of development and the mechanisms retained or reemployed to ensure an organism thrives once development is complete. To answer these questions, researchers at MDIBL use various animal models. These animals include zebrafish, killifish, axolotl, fruit flies (Drosophila), and nematodes (Caenorhabditis elegans), which can be used to compare the genetic similarities and differences in aging and regeneration strategies across species. Students will be fully integrated into the scientific culture of MDIBL through symposia, seminars, activities, responsible conduct of research training, and weekly career discussions. Students More information about the program is available in the NSF ETAP registration system and by visiting https://mdibl.org/education/student-fellowships/reu-summer-fellowships/, or by contacting the PI (Dr. Updike at [e-mail]) or the co-PI (Dr. Disney at [e-mail]).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

REU 场地授予位于缅因州巴港的沙漠岛生物实验室 (MDIBL)，将支持 10 名学生在 2023 年至 2025 年夏季进行为期 10 周的培训。预计总共 30 名学生将接受该计划的培训，他们主要来自研究机会有限的学校或代表性不足的群体。学生将处于本科学习的各个阶段，并且将特别考虑对再生和衰老的显微镜和比较动物模型研究感兴趣的申请人。学生将了解如何进行研究，许多人将在科学会议上展示他们的工作成果。该计划的评估将通过在线 SALG URSSA 工具进行。学生将被要求在 NSF ETAP 系统 (etap.nsf.gov) 中注册，并在项目结束后进行跟踪，以确定他们的职业道路。REU 项目 MDIBL 将使学生接触用于了解再生和衰老生物学的比较动物模型方法。该 REU 站点的实验室感兴趣的是细胞、组织、器官和四肢在受伤后或在正常发育过程中如何修复或补充，以及保留或重新利用的机制，以确保生物体在发育完成后茁壮成长。为了回答这些问题，MDIBL 的研究人员使用了各种动物模型。这些动物包括斑马鱼、鳉鱼、蝾螈、果蝇（果蝇）和线虫（秀丽隐杆线虫），可用于比较不同物种之间衰老和再生策略的遗传相似性和差异。学生将通过专题讨论会、研讨会、活动、负责任的研究培训和每周的职业讨论，充分融入 MDIBL 的科学文化。学生 有关该计划的更多信息，请访问 NSF ETAP 注册系统，访问 https://mdibl.org/education/student-fellowships/reu-summer-fellowships/，或联系 PI（Updike 博士，dupdike@ mdibl.org）或联合 PI（迪士尼博士，[e-mail]）。该奖项反映了 NSF 的法定使命，并被认为值得支持通过使用基金会的智力优点和更广泛的影响审查标准进行评估。