STTR Phase I: Patient-Specific System for Early Detection and Identification of Epileptic Seizures

STTR 第一阶段：早期检测和识别癫痫发作的患者特异性系统

• 批准号: 2322346
• 负责人: Saba Mehmood
• 金额: $ 27.5万
• 依托单位: AI-NEOTECH LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2322346&HistoricalAwards=false
• 关键词: STTR; Phase; Patient; Specific; System

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to provide epileptic patients, and their caregivers a smart system that can predict seizures before they occur. There are more than 3 million adults and 1 million children in the US, and more than 50 million people worldwide, suffering from epilepsy. Repeated and unpredictable seizures significantly affect the quality of life of people suffering from epilepsy. These seizures remain the leading cause of economic, emotional, and physical injuries for people with epilepsy and their caregivers. Design, development, and integration of artificial intelligence (AI) models with instruments that detect abnormalities in brain waves like electroencephalogram (EEG) for real-time seizure prediction may bring improvements for these patients and their caregivers. This technology is poised to capture a portion of the rapidly growing $6 billion US market of AI healthcare solutions.This Small Business Technology Transfer (STTR) Phase I project supports the development of a novel consumer product that works with caregivers to proactively mitigate the risk of seizure events in people with epilepsy. Current commercial solutions are mostly reactive, and support is available only after a seizure event. The company will fill this gap by developing, testing, integrating, and evaluating machine learning (ML) models - applied to EEG data - for epileptic seizure prediction. The scientific approach will leverage inherently heterogenous and complex edge technologies. Data connectivity with third party vendor EEG caps, microcontrollers, smart phones, and cloud services rely on many different operational technologies and communication standards. This research will overcome these challenges with hardware and software solutions that will integrate these services within an edge device to enable application portability and simplify deployment. Challenges such as inference on limited computational power and energy devices, and its effects on the accuracy/sensitivity of the predictions will be solved using robust cross-validation techniques, extensive testing, and benchmarking using community standards. The technical product of this research will advance caregiver knowledge and increase understanding of epileptic seizures as well as increase patient well-being.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小型企业技术转移（STTR）I期项目的更广泛的影响/商业潜力是为癫痫患者提供，其护理人员是一个智能系统，可以预测癫痫发作之前。 美国有超过300万成年人和100万儿童，全球有超过5000万人患有癫痫病。 反复和不可预测的癫痫发作显着影响患有癫痫患者的生活质量。这些癫痫发作仍然是癫痫患者及其护理人员的经济，情感和身体伤害的主要原因。人工智能（AI）模型的设计，开发和整合与检测到实时癫痫发作预测（EEG）等脑电波异常的仪器可能会为这些患者及其护理人员带来改善。该技术有望捕获美国AI医疗保健解决方案60亿美元迅速增长的一部分。该小型企业技术转移（STTR）I阶段项目支持开发新型的消费产品，该产品与护理人员合作，以主动减轻癫痫患者癫痫发作事件的风险。当前的商业解决方案主要是反应性的，并且仅在癫痫发作事件后才获得支持。该公司将通过开发，测试，集成和评估机器学习（ML）模型（应用于脑电图数据）来填补这一空白，以进行癫痫发作预测。科学方法将利用固有的异质和复杂的边缘技术。与第三方供应商EEG帽，微控制器，智能手机和云服务的数据连接依赖于许多不同的操作技术和通信标准。这项研究将通过硬件和软件解决方案克服这些挑战，这些解决方案将将这些服务集成到边缘设备中，以实现应用程序可移植性并简化部署。将使用强大的交叉验证技术，广泛的测试和使用社区标准来解决诸如计算能力和能源设备的推断及其对预测准确性/敏感性的影响之类的挑战。这项研究的技术产品将提高护理人员的知识，并提高对癫痫发作的理解，并提高患者福祉。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的智力优点和更广泛影响的评估评估来支持的。