NSF PRFB FY 2023: Considering evolutionary responses to temperature variability when predicting risk to climate change and disease in amphibians

NSF PRFB 2023 财年：在预测气候变化和两栖动物疾病风险时考虑对温度变化的进化反应

• 批准号: 2305659
• 负责人: Jennifer Cocciardi
• 金额: $ 24万
• 依托单位: Cocciardi, Jennifer M
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2305659&HistoricalAwards=false
• 关键词: NSF; PRFB; FY; 2023; Considering

This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2023, Integrative Research Investigating the Rules of Life Governing Interactions Between Genomes, Environment, and Phenotypes. The fellowship supports research and training of the fellow that will contribute to the area of Rules of Life in innovative ways. This research will address how the dual pressures of climate change and disease interact to affect one of the most endangered taxa on the planet, amphibians. While independently, climate change and emerging infectious diseases present daunting challenges to species persistence, together they can increase vulnerability by promoting pathogen growth rates, altering host immune response, and reducing host thermal tolerance. Most research in this area has focused on how temperature variability can increase the risk of disease, with few studies examining if the disease affects vulnerability to temperature extremes. Yet, understanding this is crucial, given that temperature variability and extremes are a trademark of climate change. This project will explore this question, as well as broaden diversity and increase participation in the Ecology and Evolutionary Biology field by supporting the development of an immersive summer experience for underrepresented high school students in amphibian disease ecology.This research will take an interdisciplinary approach to understand how the fungal pathogen Batrachochytrium dendrobatidis (Bd) increases vulnerability to temperature variability in an amphibian host species. To do so, this project will quantify the relationship between disease prevalence, environment, phenotype, and genotype in the northern cricket frog (Acris crepitans), resulting in a predictive risk model. Specifically, the research will consider the importance of evolutionary responses to temperature variability and extreme events when predicting the risk to climate change and disease. The fellow will conduct an observational survey correlating local variation in thermal traits to Bd prevalence and microhabitat temperatures, an empirical experiment investigating if and how Bd alters thermal physiology, and a quantitative genetics experiment relating phenotypes to population-level genetic variance to predict the adaptive potential of thermal traits. This project will culminate in a predictive risk model that links Bd infection dynamics, host demography, thermal performance, and evolution to understand population-level resilience to changing wildlife disease dynamics under future climate change scenarios. This project will involve training the fellow in wildlife disease ecology and disease modeling, as well as providing opportunities to practice inclusive pedagogy through training and outreach.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该行动为2023财年生物学的NSF博士后研究奖学金提供了资金，该研究综合研究调查了有关基因组，环境和表型之间相互作用的生活规则。奖学金支持对研究员的研究和培训，这些研究和培训将以创新的方式为生活规则做出贡献。这项研究将解决气候变化和疾病的双重压力如何影响地球上两栖动物最濒危的类群之一。虽然独立地，气候变化和新兴的传染病对物种持久性带来了艰巨的挑战，但它们可以通过促进病原体生长速率，改变宿主免疫反应并降低宿主的热耐受性来增加脆弱性。该领域的大多数研究都集中在温度可变性如何增加疾病的风险上，很少有研究检查该疾病是否影响了极端温度的脆弱性。然而，鉴于温度可变性和极端是气候变化的商标，理解这一点至关重要。 This project will explore this question, as well as broaden diversity and increase participation in the Ecology and Evolutionary Biology field by supporting the development of an immersive summer experience for underrepresented high school students in amphibian disease ecology.This research will take an interdisciplinary approach to understand how the fungal pathogen Batrachochytrium dendrobatidis (Bd) increases vulnerability to temperature variability in an amphibian host species.为此，该项目将量化北部板球青蛙（Acris Crepitans）中疾病患病率，环境，表型和基因型之间的关系，从而产生了预测性风险模型。具体而言，该研究将在预测气候变化和疾病的风险时，考虑对温度变化和极端事件的进化反应的重要性。该研究员将进行一项观察性调查，将热性状的局部变化与BD患病率和微栖息地温度相关联，经验实验研究了BD是否以及如何改变热生理学以及如何改变热生理学，以及定量遗传学实验将表型相关的表型与人群级别的遗传变异相关，以预测热特性的自适应性。该项目将在预测风险模型中达到顶峰，该模型将BD感染动态，宿主人口统计学，热性能和演变联系起来，以了解在未来气候变化情景下改变野生动植物疾病动态的人群水平的韧性。该项目将涉及培训野生动植物疾病生态和疾病模型的研究员，并提供通过培训和宣传来实践包容性教学法的机会。该奖项反映了NSF的法定任务，并认为值得通过基金会的知识分子优点和更广泛的影响来通过评估来进行评估。