SBIR Phase I: Sustainable antioxidants for industrial process fluids

SBIR 第一阶段：工业过程流体的可持续抗氧化剂

• 批准号: 2222215
• 负责人: Sherri Elder
• 金额: $ 25.3万
• 依托单位: NEW PAGE STRATEGIC CONSULTING, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2222215&HistoricalAwards=false
• 关键词: SBIR; Phase; Sustainable; antioxidants; industrial

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to develop bio-based antioxidant products for industrial processes. Commercial development of peptide antioxidants has been limited for use in consumer, food, or therapeutic applications. This project will develop peptide antioxidants derived from the enzymatic digestion of agricultural biomass as alternatives to synthetic antioxidants used in the processing and storage of industrial fluids. Although synthetic antioxidants are critical for the stabilization of many industrial processes, they are derived from petroleum and tend to have toxicity and/or environmental safety concerns. The products resulting from this effort will be first-in-class innovations; safer and more environmentally responsible than existing products. Project activities will validate peptide performance in the initial target application area: the stabilization of vinyl monomer fluids and processes. This research will initially focus on vinyl monomer processing as well as four additional industrial markets where sustainable antioxidants could have a high impact. The estimated consumption of synthetic antioxidants in the five combined markets in 2022 will be close to 1 million tons.This SBIR Phase I project seeks to develop a bio-based antioxidant product derived from sustainable materials and suitable for industrial process fluids. Antioxidant peptides derived from the enzymatic digestion of plant-based proteins have the potential to replace synthetic antioxidants in industrial processes. This project focuses on process compatibility, product stability, and antioxidative performance as key technical hurdles. This project will create a library of antioxidative peptides generated by the enzymatic digestion of plant proteins. This library will then be tested for the solubility of peptides with representative fluids under process conditions, potential formulation design, and for thermal and storage stability of the designed formulations. This project will lower technical barriers to advancing the commercial development of peptide antioxidants for applications across many industries.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小型企业创新研究 (SBIR) 第一阶段项目的更广泛影响/商业潜力是开发用于工业过程的生物基抗氧化剂产品。肽抗氧化剂的商业开发仅限于消费、食品或治疗应用。该项目将开发源自农业生物质酶消化的肽抗氧化剂，作为工业流体加工和储存中使用的合成抗氧化剂的替代品。尽管合成抗氧化剂对于许多工业过程的稳定至关重要，但它们源自石油，并且往往存在毒性和/或环境安全问题。这一努力产生的产品将是一流的创新；比现有产品更安全、更环保。项目活动将验证肽在最初目标应用领域的性能：乙烯基单体流体和工艺的稳定性。这项研究最初将重点关注乙烯基单体加工以及可持续抗氧化剂可能产生重大影响的四个其他工业市场。预计到 2022 年，五个综合市场的合成抗氧化剂消耗量将接近 100 万吨。该 SBIR 一期项目旨在开发一种源自可持续材料且适用于工业工艺流体的生物基抗氧化剂产品。植物蛋白酶消化产生的抗氧化肽有可能取代工业过程中的合成抗氧化剂。该项目重点关注工艺兼容性、产品稳定性和抗氧化性能作为关键技术障碍。该项目将创建一个通过植物蛋白酶消化产生的抗氧化肽库。然后，该库将在工艺条件下测试肽与代表性流体的溶解度、潜在的配方设计以及设计配方的热稳定性和储存稳定性。该项目将降低技术壁垒，推动肽抗氧化剂的商业开发，应用于许多行业。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。