CCI Phase I: NSF Center for Chemoenzymatic Synthesis

CCI 第一阶段：NSF 化学酶合成中心

基本信息

批准号：
2221346
负责人：
Karl Scheidt
金额：
$ 180万
依托单位：
Northwestern University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2221346&HistoricalAwards=false
关键词：
CCI Phase NSF Center Chemoenzymatic

项目摘要

The Center for ChemoEnzymatic Synthesis (C-CES) is supported by the Centers for Chemical Innovation (CCI) Program in the Division of Chemistry. Enzymes are proteins that control and catalyze chemical reactions essential for life. Nature’s ability to employ these highly evolved biological catalysts to generate diverse and complex molecules through selective reactions has inspired chemists for decades and has led to the field of biocatalysis. The potential societal impacts of biocatalysis are significant, yet chemists have only recently begun to leverage these efficient and selective natural processes. C-CES seeks to develop unprecedented transformations and achieve new selectivity strategies by applying novel concepts in biocatalysis to sustainable making of chemicals, which are referred to as chemoenzymatic synthesis. These advances will allow the scientific community to address 21st-century challenges in the production of new medicines and materials. The broader impacts of the Center will focus on convergent, interdisciplinary education of early career scientists in chemoenzymatic synthesis, team building, and communication, all which will build the foundation for their independent careers. The Center will be at the forefront of developing and disseminating resources to integrate biocatalysis into broad practice across university and industrial settings, as well as in chemistry courses and laboratories. Finally, the Center will build up existing institutional resources of each team member to recruit, engage, and educate individuals from underrepresented groups, thereby broadening the impact of chemoenzymatic synthesis. C-CES will drive an unexplored frontier of organic synthesis by enabling new discoveries in biocatalysis and chemoenzymatic synthesis. The Center will focus on the grand challenge of creating new selective reactions for carbon-carbon and carbon-heteroatom bond formation in a sustainable manner by combining biocatalytic and bioinspired transformations with established chemical synthesis methodologies. Center activities will integrate fundamental concepts and past success of small molecule catalysis with the unique advantages of efficiency and selectivity control available through supramolecular protein-based catalysts. The Center will bring together internationally recognized scientists with complementary areas of expertise in catalysis, organic synthesis, chemoenzymatic synthesis, machine learning, high-throughput experimentation, protein engineering and biocatalysis. The two initial goals of the Center are the biocatalytic formation of high value C–C and C–X bonds and controlling selectivity outcomes currently unobtainable through conventional strategies. The realization of these efforts will be driven by a collaborative and convergent approach to experimental research and student training that combines state-of-the-art strategies for reaction development and biocatalyst design with machine learning and retrosynthesis planning. The Center will oversee coordinated training activities to ensure C-CES participants acquire diverse knowledge and techniques needed to master and then utilize biocatalysis in synthesis. The main broader impacts of this award include: a) the development of biocatalysis workshops to train future scientists on practical strategies and approach to chemoenzymatic synthesis; b) curriculum development around biocatalysis concepts for the broader chemical community; and c) public engagement regarding the sustainable applications of chemoenzymatic synthesis to access innovative materials that impact our everyday lives.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

化学酶合成中心 (C-CES) 得到化学部化学创新中心 (CCI) 项目的支持。酶是控制和催化生命所必需的化学反应的蛋白质，大自然能够利用这些高度进化的生物催化剂。通过选择性反应生成多样化和复杂的分子几十年来一直激励着化学家，并催生了生物催化领域。生物催化的潜在社会影响是巨大的，但化学家最近才开始利用这些影响。 C-CES 致力于通过将生物催化中的新概念应用于化学品的可持续制造（称为化学酶合成）来开发前所未有的转化并实现新的选择性策略。该中心的更广泛影响将集中于对早期职业科学家在化学酶合成、团队建设和交流方面的融合、跨学科教育，所有这些都将为他们的独立职业生涯奠定基础。将处于开发和传播资源的前沿，将生物催化整合到大学和工业环境以及化学课程和实验室的广泛实践中。最后，该中心将建立每个团队成员的现有机构资源，以招募、参与、参与。并教育来自代表性不足群体的个人，从而扩大化学酶合成的影响，C-CES 将通过实现生物催化和化学酶合成的新发现来推动有机合成的新领域。通过将生物催化和生物启发转化与现有的化学合成方法相结合，以可持续的方式创建碳-碳和碳-杂原子键形成的新选择性反应。中心活动将把小分子催化的基本概念和过去的成功与效率和独特的优势结合起来。该中心将汇集在催化、有机合成、化学酶合成、机器学习、高通量实验、蛋白质工程和化学领域具有互补专业知识的国际知名科学家。该中心的两个最初目标是生物催化形成高价值的 C-C 和 C-X 键，以及控制目前通过传统策略无法获得的选择性结果，这些努力的实现将通过协作和聚合的实验方法来推动。研究和学生培训将最先进的反应开发和生物催化剂设计策略与机器学习和逆合成规划相结合，该中心将监督协调的培训活动，以确保 C-CES 参与者掌握并掌握所需的各种知识和技术。该奖项的主要广泛影响包括：a）举办生物催化研讨会，以培训未来的科学家进行化学酶合成的实用策略和方法；b）为更广泛的化学界开发生物催化概念的课程；公众参与化学酶合成的可持续应用，以获得影响我们日常生活的创新材料。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。