MRI: Acquisition of a CryoProbe 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

MRI：采购 CryoProbe 500 MHz 核磁共振 (NMR) 波谱仪

• 批准号: 2215973
• 负责人: Alison Frontier
• 金额: $ 60.53万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2215973&HistoricalAwards=false
• 关键词: MRI; Acquisition; CryoProbe; 500; MHz

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. The University of Rochester is acquiring a 500 MHz Nuclear Magnetic Resonance (NMR) spectrometer with a liquid nitrogen cooled probe to support the research of Professor Alison Frontier and colleagues Rudi Fasan, Caitlyn R. Kennedy, and Shauna M. Paradine. This instrument facilitates research in the areas of synthesis, peptide chemistry, catalysis, and materials chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The nitrogen-cooled probe provides a significant increase in sensitivity relative to standard NMR probes. This instrument enhances the educational, research, and teaching efforts of students at all levels in the department. Accessibility of the instrument to science and engineering students promotes their training for future careers.The award of the 500 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as synthetic organic and inorganic chemistry, polymer science, biochemistry, and biophysics. This instrument enables research focused on the synthesis of complex natural products and other biologically relevant polycycles, catalytic methods for asymmetric synthesis, C-H functionalization of bioactive molecules, and transition metal catalyzed C-C bond formation. It also assists in the preparation of molecular mimics of inorganic and hybrid porous materials and in the dehydrogenation and dehydration of alcohols and amines. Other investigations include the synthesis, characterization, and reactivity of polyoxovanadate-alkoxide clusters and using iron-catalyzed transformations in organic synthesis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由重大研究仪器项目和化学研究仪器项目联合资助。罗彻斯特大学正在购买一台带有液氮冷却探头的 500 MHz 核磁共振 (NMR) 波谱仪，以支持 Alison Frontier 教授及其同事 Rudi Fasan、Caitlyn R. Kennedy 和 Shauna M. Paradine 的研究。该仪器促进了合成、肽化学、催化和材料化学领域的研究。一般来说，核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于进行前沿研究的化学家来说，使用最先进的核磁共振波谱仪至关重要。与标准 NMR 探头相比，氮气冷却探头的灵敏度显着提高。该工具增强了系内各级学生的教育、研究和教学工作。科学和工程专业的学生使用该仪器可促进他们未来职业的培训。500 MHz NMR 波谱仪的获奖旨在加强各个层面的研究和教育，特别是在合成有机和无机化学、高分子科学、生物化学等领域和生物物理学。该仪器可集中研究复杂天然产物和其他生物相关多环化合物的合成、不对称合成的催化方法、生物活性分子的 C-H 官能化以及过渡金属催化的 C-C 键形成。 它还有助于制备无机和杂化多孔材料的分子模拟物以及醇和胺的脱氢和脱水。其他研究包括多氧钒酸盐-醇盐簇的合成、表征和反应性，以及在有机合成中使用铁催化转化。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。